ID A0A396RNC7_9SPHN Unreviewed; 369 AA.
AC A0A396RNC7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=D1610_04890 {ECO:0000313|EMBL:RHW17859.1};
OS Sphingomonas gilva.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=2305907 {ECO:0000313|EMBL:RHW17859.1, ECO:0000313|Proteomes:UP000266693};
RN [1] {ECO:0000313|EMBL:RHW17859.1, ECO:0000313|Proteomes:UP000266693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZDH117 {ECO:0000313|EMBL:RHW17859.1,
RC ECO:0000313|Proteomes:UP000266693};
RA Zhu D., Zheng S.;
RT "The multiple taxonomic identification of Sphingomonas gilva.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW17859.1}.
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DR EMBL; QWLV01000002; RHW17859.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A396RNC7; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000266693; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RHW17859.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000266693};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 59..107
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 120..294
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 369 AA; 41345 MW; D9FAB6C44B3A6011 CRC64;
MGLRCWVSAP QQARHAQVPE RCDGPAHWKA QAKGAAVATK IAYVDDGLPG ITRRKAGKGW
AYFDAKGKRI TDRDEIDRLN AVGMPPAYRD CWFCPSADGH IQATGYDDKG RKQYRYHLEF
RARQEAAKYD LCADFGRALP LLRARVESDL RRRRLGRDQA IASVVRLLDL GRVRVGNEGY
AKENKSFGAT TLRKRHADVR GKTLSLEYRA KSGKLRVMKV TDGTLTRFVK QMQDLPGQQL
FKWTDEDGAC HVVTSTIVND YIREAMGEDF TAKHFRTWGA SVLAFEALAE AKEPLSLAAM
LDPVIQALGN TPAIARKSYV HPRLIDLTKT GQKAFREGLK LPRATRYLSR HERGLIELLD
SPAPRAKAA
//
