ID A0A396TYD6_9GAMM Unreviewed; 810 AA.
AC A0A396TYD6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Cadmium-translocating P-type ATPase {ECO:0000313|EMBL:RHW77003.1};
DE EC=3.6.3.3 {ECO:0000313|EMBL:RHW77003.1};
GN Name=cadA {ECO:0000313|EMBL:RHW77003.1};
GN ORFNames=D1094_03650 {ECO:0000313|EMBL:RHW77003.1};
OS Colwellia sp. RSH04.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Colwellia.
OX NCBI_TaxID=2305464 {ECO:0000313|EMBL:RHW77003.1, ECO:0000313|Proteomes:UP000266369};
RN [1] {ECO:0000313|Proteomes:UP000266369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSH04 {ECO:0000313|Proteomes:UP000266369};
RA Meng X.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW77003.1}.
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DR EMBL; QXIO01000002; RHW77003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A396TYD6; -.
DR OrthoDB; 9814270at2; -.
DR Proteomes; UP000266369; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:UniProt.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02079; P-type_ATPase_HM; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR021993; ATPase-cat-bd.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01512; ATPase-IB2_Cd; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF5; CATION-TRANSPORTING P-TYPE ATPASE-RELATED; 1.
DR Pfam; PF12156; ATPase-cat_bd; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Hydrolase {ECO:0000313|EMBL:RHW77003.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000266369};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 179..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 434..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 461..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 764..783
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 789..807
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 91..157
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 810 AA; 88954 MW; 6089A56B982701B0 CRC64;
MNTRCFHCAE FIPKGISLFV SINNIEQPMC CLGCQAVAQT IVDNNLTQYY QVRTEPAHKG
QALIPEQLEK NKLLDEEVLQ NEFIYHAQDY KEAILTIDGI SCAACAWLIE MQIAKVSGVV
SINVNATTQR ATVQWQDDTV NLSDILTAIE HIGYQALPFK ANEAEVRNKK HSKTFIKRLG
ISGILMMQVM MIAVGLYFGA FADMAEHNKV YLRWISFILT IPIITYGAFP FYIGAINALK
VKRLSMDVPV SIAIILAFSA SAWATVSQQG EVYFESVSMF TFLLLIGKFL EFRARSRAAQ
VSANLLKLMP MTALKIIIDN EEEVTSSQNQ EKLIAAKQLI KDDFVLIKPG EVIPADGIII
KGKSQLNEAM LSGEQLPVNK SVDDKVFAGT INGDSNLIVK VSQASNQSFL SQLIRLSEHS
QAHKPKLAKF SDKVAQYFVA IILCTAIGTA IYWQQHLPEE AFWITLSVLV ATCPCALSLA
TPTALTCATT RLNKNGIMIK SAHVMETMPQ VDSFAFDKTG TITDGEFSIA DVQHENNIKK
DDVLAIAAAL EAQSEHPLAK PFHQYRNYQL QVSNIEVHSG QGVSGTVNNV HYKIGKPNWL
LSDTALLNYQ DRTCVLVKNN SLTNETEVLA SFSLIDKIRD EAVALINTLN THANTLLLSG
DSQLACDKLM QNVPIKMARG GLTAEHKMQI IKTEQASKHR VAMTGDGVND SPVFGAAHVS
IAMGCGADIA KSGADVILLN NRLSSISTLI NVAKKTKKII FQNYLWAFGY NAIVLPLAVA
GFITPYMAVI GMSASSILVI TNSLRLLKNN
//
