ID   A0A396U4V8_9GAMM        Unreviewed;       504 AA.
AC   A0A396U4V8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Tryptophan 7-halogenase {ECO:0000313|EMBL:RHW77539.1};
GN   ORFNames=D1094_00890 {ECO:0000313|EMBL:RHW77539.1};
OS   Colwellia sp. RSH04.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Colwellia.
OX   NCBI_TaxID=2305464 {ECO:0000313|EMBL:RHW77539.1, ECO:0000313|Proteomes:UP000266369};
RN   [1] {ECO:0000313|Proteomes:UP000266369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSH04 {ECO:0000313|Proteomes:UP000266369};
RA   Meng X.;
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHW77539.1}.
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DR   EMBL; QXIO01000001; RHW77539.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A396U4V8; -.
DR   OrthoDB; 7178350at2; -.
DR   Proteomes; UP000266369; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266369}.
FT   ACT_SITE        77
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         77
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         333
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         342
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         346
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   504 AA;  57275 MW;  4ADCCEBB0F064B57 CRC64;
     MKIKKIAIVG AGTAGWLAAN HLGSELQHED IQITVIESDK VPTIGVGEGT VPYIMKGLER
     FGISEAELLI SCDATFKQGI KFVNWMKPEQ EKEHFYYHPF DSPYPAGFDI SRHMSNLETS
     RPFDDVGIQA RICELGLAPK RKSSAEYQGD LAYAYHFDAA KFAKLLANNA IKKFNVNHVI
     ATILGAKKDS AGNITHLLTD EDSELAFDFY IDCSGFSSVL IEKELSVPFV KKDKELLTDT
     VLVQQVPISE SEALNPYTTA TAHKAGWVWD IPLTTRRGTG FVYSSQHMSE TEAKACYAKY
     LGVNEKDFSP RKIPMDIGYR ESFWQKNCVA LGLAQGFLEP LEATSILLSD FSAEMLAKNF
     PRTFSDIDCS YQYYNKVVTY AWERTVDFIK LHYCLSDRDD SEFWQQNSDK DALSAELKQR
     LNKFKLRPPL QSDFFSRFDL FNEKNFLYVL YGMNFNTQKA ITSEKEQRHS EQLLEQNDQL
     VKQAANILLN HKEWLMALKA AMSE
//