ID A0A397G944_9EURO Unreviewed; 1122 AA.
AC A0A397G944;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDV56_102048 {ECO:0000313|EMBL:RHZ47511.1};
OS Aspergillus thermomutatus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=41047 {ECO:0000313|EMBL:RHZ47511.1, ECO:0000313|Proteomes:UP000215305};
RN [1] {ECO:0000313|EMBL:RHZ47511.1, ECO:0000313|Proteomes:UP000215305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMR AF 39 {ECO:0000313|EMBL:RHZ47511.1,
RC ECO:0000313|Proteomes:UP000215305};
RA Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA Perkins V., De Repentigny L., Dufresne S.F.;
RT "Draft genome sequence of azole-resistant Aspergillus thermomutatus
RT (Neosartorya pseudofischeri) strain HMR AF 39, isolated from a human nasal
RT aspirate.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHZ47511.1}.
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DR EMBL; NKHU02000219; RHZ47511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A397G944; -.
DR STRING; 41047.A0A397G944; -.
DR VEuPathDB; FungiDB:CDV56_102048; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000215305; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000215305};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 27..93
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 656..776
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 836..1079
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 124250 MW; FEDC089AE717AFAB CRC64;
MSPPLTPYCA TSSKDNSMDR TEPSRAVFHN YLRAFYPFHP PGDVSPATIT LPLDQGDIIL
VHSVHTNGWA DGTLLDTGAR GWLPTNYCEA YDQLPMRPLL KALTDFWDII RGGCGSSLRD
FGNQDLVRGL IAGVRFLLEK SECLTRDSFL VRRHDGLRRN RKALLSDLTA LVRTTKSFQV
IASGNPLEDE VEYLVDEMLL KAFRVVTRGV RFLDIWNEEV GLSRTIAELE QTKDYASPPT
PASETFAISE AAPSETETER NESRVLNRSC MSMSRCSARM DMSEQPRPVS VATKRISISH
RVSYSGPAAA ARNPNLASER LNATYDAFLG VLGSFIGLHL QSRSSTELVV TTEQAVRSCR
GLLTVVEAVC EHDSQGSALL ERAKDTMYER LSELVFAARD AFRPAQSPDD ELVFMPDEGK
RLVDAATDCV RAAGNCLAKA RLVLEQVGDF ELEALPQDVA TPLVGARPES QLQQQKGDQT
GTSLRLPPPP LQIPQNTDLD YSPPTPGLTD DTTPSSFNSR MLSSPTIAAT DATSLPSTTI
LSTSPEKTSF SSSYDATVGV KILENRISHP KSEVGESFGR GVTSTGSSFT YHSHLRDSEM
SGVSQTSTRA TSPDIGCSYQ APSLKSSVSH STLAEEGEET EVNILEKTYA HELIFKDGQV
MGGSLRALIE KLTAHGSTPD AMFVSTFYLT FRLFATPLEF AEALADRFDY IGDTPHAAGP
VRLRVYNVFK GWLESHWRHD CDTSALDFIV NFANTTLMQS LPSAGKRLLE LTDKVSTLQG
PVVPRLVSSM GKTNTATAQY VHPDTPLPPP ILGKKEVNLL KQWKNGEAAI SILDFDPMEL
ARQFTIKESR IFCAILPEEL LATEWMKKSA SLAVNVRAMS TLSTDLAHLV ADSILQLEEP
KKRAAIIKHW VKIANKCLEL NNYDTLMAII CSLNSSMISR LKRTWEVVSQ KTKTTLEILR
GIVDVSRNYA VLRQRLQTHV PPCLPFVGTY LTDLTFVDHG NQPLRSLPTD DGEMAVINFD
KHMKTAKIIS ELQRFQIPYR LTEVPELQTW MQNELVRVRS NGEKSLQTFY RRSLILEPRE
ITQRPSLQPE SSASSILENA KDKFDLFSWT HPSKAKSVAT NG
//
