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Database: UniProt
Entry: A0A397GAL2_9EURO
LinkDB: A0A397GAL2_9EURO
Original site: A0A397GAL2_9EURO 
ID   A0A397GAL2_9EURO        Unreviewed;      1939 AA.
AC   A0A397GAL2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   13-SEP-2023, entry version 16.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=CDV56_102102 {ECO:0000313|EMBL:RHZ48052.1};
OS   Aspergillus thermomutatus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=41047 {ECO:0000313|EMBL:RHZ48052.1, ECO:0000313|Proteomes:UP000215305};
RN   [1] {ECO:0000313|EMBL:RHZ48052.1, ECO:0000313|Proteomes:UP000215305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMR AF 39 {ECO:0000313|EMBL:RHZ48052.1,
RC   ECO:0000313|Proteomes:UP000215305};
RA   Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA   Perkins V., De Repentigny L., Dufresne S.F.;
RT   "Draft genome sequence of azole-resistant Aspergillus thermomutatus
RT   (Neosartorya pseudofischeri) strain HMR AF 39, isolated from a human nasal
RT   aspirate.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHZ48052.1}.
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DR   EMBL; NKHU02000206; RHZ48052.1; -; Genomic_DNA.
DR   STRING; 41047.A0A397GAL2; -.
DR   VEuPathDB; FungiDB:CDV56_102102; -.
DR   OrthoDB; 147843at2759; -.
DR   Proteomes; UP000215305; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215305};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1340..1523
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1636..1923
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   REGION          1613..1655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1630..1655
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1939 AA;  216289 MW;  89D2BBCC46401916 CRC64;
     MDCFFTNIRR CALDKLATLS VTEAGCDDLS DLTRLSQQCP HPSSRSNVSP DGVVNNKTTI
     SQLPMDSREL DVLLALCDAA PSVTEFEHAS KLATQLFPYL PESHSQCFRP SPFLNNMKPS
     PWETLTRKLT SSLLSLGSNH PALRSTTLSA VNEYLYSCAD SIDAITPLQR YDSAGDNYGA
     VQEHKRILSL AVSLVGFLEA SAQFPSLWSA SEKLQIVEHV RSMLSEGFMV AIETASSTVR
     NASMADPTLR DWRRYTRRYA ANRRPLGAML LQQGFMRFVK SCATSLVGAQ SLSDEELLDD
     YMNGVGIARS NDDAEITLID RITEIIADEI QLLEDGSDYL QLGSPWQKQL TFSVKSFALI
     GYLNCVILSG NAANSGAFLS WLEDALADPN QMASLELATA TLKSIAIISR MSLASASSGS
     RSLLRFIIEG CVLGEHTGSV AGKCLAQVLG ILSQDAIITT LYSLGNALSP GSGTDKYYHG
     QLLNENAGHP DSVSSIPPPV GNGSVVSLSA IGDHDNATCR NILRAIVTIA TSSNDEKISA
     LAQSMLLQKI GKVNIAVDSL IIRETASLSL STGQAEFQLL LKFYDRAYQD GITRNLCDVM
     NAVKGAMTYI SLALRRDSPL FRVYLIHLLE CIVNKGDAIG EGERQKEVIL APEAISFLLR
     PLALLISSDE EETGTQQTDV IFDEDITALF RDAWFNISVH GISTQSVVAQ SHIRELRLLA
     KHSPPLIAES RMEMLESDVE LNTILRRGMS PQRLIELKRI LMAELPDCES GIKHLNYPKV
     VFLNASLLVE SLRASSGNCT KVLSYFRDPA LTTADMANCM SSIADKVVAD YLSLTLSAND
     ENFSVPYLSK ELAQFFMACC HRIERVQSVA MLCADKIIRE CPSALCDKHS LFALLELLTV
     MWLSCLEEEL DEFEWKASCA SPMGIVKVDL ADNYNARKRT LNTLLERAKA WVAAVIDIAP
     LDTYLSISND TVDGSHILLG RSFALDMGST IPRSDQRLGC IQSSGISRVN VASDFIAQYT
     IRQQYRASDL LVTKYLEQGS IENNGEDCGK IARGLLESSE HVKNMLHRLH DQLKAGNGVV
     LSEFRDTLRR AAAVLCGSDY FQPSILHYLV ILPFQLFSEE SMNVGVALWL GAIHENPKLE
     PRILAEVIEA WEETIQRRRG LFDLSFDYVD PMYAKIELLP SDKALLLKKQ QKAQATFAPH
     LIALRFFESH FNAVRLNSAQ NSRLFGRLID RTTVGLLQTS GHPLARELHF RIVLFGLRVI
     QDSYQPDKVA LWKLSDQILS AALNWFKHPP RWSFGGNRLQ VKAEDQILDD VARALGRLST
     VPSPTRGNFK PLQYKHDLLQ LLIEHERSRL RVWLFPLEGE RKHFQISGNR NSAEEAIHLL
     RLAWTESPGL AIQLSSRYSS SKMKNDIRWL LLNFPEKALD EPSSLEVMLG AALPSDVSFQ
     LKYAMRALES HPIDVRFYFV PQLVQALRYD ALGYVERYIL ETAKQSQLFA HQVIWNMKAN
     SYKDEDSQIP DPLKPTLDRF MDTLISSFSD EERDFYEREF SFFNDITGIS GKLRPYIKKS
     KPEKKAKIEE ELRKIKVEIG VYLPSNPDGV VVGIDRKSGK PLQSHAKAPY MATFRIQKTR
     NRGDERDSQG PSRPNTSSHD DSTKTLSAPL HSPSSQETYE VWQSAIFKVG DDCRQDMLAL
     QMIAAFRSIF ASAGLDVWVF PYRVTSTAPG CGVIDVLPNS ISRDMLGREA VNGLYDYFIS
     KYGGEHSTRF QEARTNFVKS MAAYSVISYL LQFKDRHNGN IMIDDAGHII HIDFGFCFDI
     APGGVRFERA PFKLTSEMVA VMSGTSHPHI HSHGGSNGGH SSNPTSTQPY RWFESLVIKA
     FLASRPFCTK LSHIVSLMLD SGLPCFKPDT LKNFRDRFVL EKNEREAAEY MRDLIRKSYM
     SVSTKGYDQF QLLTNGIPY
//
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