ID   A0A397GFM1_9EURO        Unreviewed;       740 AA.
AC   A0A397GFM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=DUF676 domain-containing protein {ECO:0000259|Pfam:PF05057};
GN   ORFNames=CDV56_100409 {ECO:0000313|EMBL:RHZ49822.1};
OS   Aspergillus thermomutatus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=41047 {ECO:0000313|EMBL:RHZ49822.1, ECO:0000313|Proteomes:UP000215305};
RN   [1] {ECO:0000313|EMBL:RHZ49822.1, ECO:0000313|Proteomes:UP000215305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMR AF 39 {ECO:0000313|EMBL:RHZ49822.1,
RC   ECO:0000313|Proteomes:UP000215305};
RA   Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA   Perkins V., De Repentigny L., Dufresne S.F.;
RT   "Draft genome sequence of azole-resistant Aspergillus thermomutatus
RT   (Neosartorya pseudofischeri) strain HMR AF 39, isolated from a human nasal
RT   aspirate.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the putative lipase ROG1 family.
CC       {ECO:0000256|ARBA:ARBA00007920}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHZ49822.1}.
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DR   EMBL; NKHU02000171; RHZ49822.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A397GFM1; -.
DR   VEuPathDB; FungiDB:CDV56_100409; -.
DR   OrthoDB; 70376at2759; -.
DR   Proteomes; UP000215305; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR48182; PROTEIN SERAC1; 1.
DR   PANTHER; PTHR48182:SF2; PROTEIN SERAC1; 1.
DR   Pfam; PF05057; DUF676; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215305};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          25..168
FT                   /note="DUF676"
FT                   /evidence="ECO:0000259|Pfam:PF05057"
FT   REGION          290..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..309
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  82362 MW;  219F783848ED6CCC CRC64;
     METENEFPFL QEVYTPPSQP KIDFVFVHGL NPRGRNDHPY ETWRHQNGTF WPRDYLPQDI
     PHARVFVYGY NSNVTNPQTM STAGVKDHAN TLLNLLDLER SPQLNTRPPK IVFIGHSLGG
     LVIKQALLNA HEDPKYTAIR LATCGLVFFG TPHRGAKGVE VGKIAAKVAR FVSKGHASNE
     LLDCLEYNSL FTRQMSSRFS HQLEDYRVVS FVEGKEVLLG GAGPASVSHL VVDEESAVLG
     LPGNRETRLK LDADHSQMCK VGSRGPMYKL IKGNIKQIVD QVLVAEQGYI PQPSTSPHPG
     PPLPPRMHTN SSSPYPNAAP QTNTPRVVGT MYAAVDSDPR SIQAAEHKNA GRWDQARNLE
     YAIFQEHLRT LGPDHNSTIV AGYHLAEIDL EASYLAKATE WCKWVSDQSQ RTLGPRHPLT
     LRAESLMGEI LCARGRYQES ESVCANVLAR QQMSIGDDDL DTLETRRRLS MAYSNLGQEQ
     NAMSIAEKRH EALQRILGPQ HIRVLSSALD TIEVLITART SNGDKILEMR FSGEIAQTTS
     QTGQIARELN DLLGPRHPLS IRALRLQGIL EMLAQNSTVA SETLRRALAT AEETLGPDHT
     ESMALVATIG IMYTLHSDRG NYIAFVMPGS SNNKLEMAAP WLTRYLSWAE TRKGKDSGDV
     QSMLDMLANL HFARQQYAEA HKYYDRLVES YQAAGMPVPQ LVATNLQTCR MHTMLLTQYS
     PRGTGSAIEG ILNSFVKKRF
//