ID A0A397GZ47_9EURO Unreviewed; 885 AA.
AC A0A397GZ47;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Mitochondrial escape protein 2 {ECO:0000256|ARBA:ARBA00020222, ECO:0000256|RuleBase:RU367108};
GN Name=YME2 {ECO:0000313|EMBL:RHZ55649.1};
GN ORFNames=CDV56_103599 {ECO:0000313|EMBL:RHZ55649.1};
OS Aspergillus thermomutatus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=41047 {ECO:0000313|EMBL:RHZ55649.1, ECO:0000313|Proteomes:UP000215305};
RN [1] {ECO:0000313|EMBL:RHZ55649.1, ECO:0000313|Proteomes:UP000215305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMR AF 39 {ECO:0000313|EMBL:RHZ55649.1,
RC ECO:0000313|Proteomes:UP000215305};
RA Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA Perkins V., De Repentigny L., Dufresne S.F.;
RT "Draft genome sequence of azole-resistant Aspergillus thermomutatus
RT (Neosartorya pseudofischeri) strain HMR AF 39, isolated from a human nasal
RT aspirate.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC controlling the mtDNA escape. Involved in the regulation of mtDNA
CC nucleotide structure and number. May have a dispensable role in early
CC maturation of pre-rRNA. {ECO:0000256|ARBA:ARBA00025276,
CC ECO:0000256|RuleBase:RU367108}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC ECO:0000256|RuleBase:RU367108}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367108}.
CC -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000256|ARBA:ARBA00010320,
CC ECO:0000256|RuleBase:RU367108}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHZ55649.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NKHU02000097; RHZ55649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A397GZ47; -.
DR STRING; 41047.A0A397GZ47; -.
DR VEuPathDB; FungiDB:CDV56_103599; -.
DR OrthoDB; 1384689at2759; -.
DR Proteomes; UP000215305; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR018850; Mt_escape_2_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR039627; Yme2_C.
DR PANTHER; PTHR32198; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR PANTHER; PTHR32198:SF2; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR Pfam; PF10443; RNA12; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367108};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU367108};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU367108};
KW mRNA processing {ECO:0000256|RuleBase:RU367108};
KW Reference proteome {ECO:0000313|Proteomes:UP000215305};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176,
KW ECO:0000256|RuleBase:RU367108};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367108};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367108}.
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367108"
FT DOMAIN 243..335
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 885 AA; 100449 MW; 5B089BBF292B3B54 CRC64;
MKITADCIGV TRATIIDVIR RDQASPHRDV PLYVHHSTLN IFCNTLLQSS KKYVIVATMI
RTRIPGLVPR ICQTPLPCKP PPTQLTRVRY ARLSTSPAVS WLETGHIDLK EDEGLLFVNN
IFPSKLQWLL LGPLSGMRSY EETVKRINRP HWAASDTFQI IQRVVPENLN IEVKQVVPRF
REGGAFVKYT RRSNVDDADI EASIKENLRE HPIRPWFNPF QEVKVSRVIG RPWIEDLYRI
PSPRLKVAFH PVSPEASAAD LSTETLYTLF RPYGKIRDID KQPSDSKVTP RYAFVEFSRP
MYAGMAKNCM HGFTVPEQEG GGKSGTRLKI KYERKIKLSM IKDWLLSHPR IVIPVLAALL
AAITVTIFDP MRTFFIKLKV KSTLQKEEDG AMQWIRNQVN KANIIYFGRK GADPRGLTAI
WEDRQDDITR LQSWLMENVE TFIVVHGPRG SGKRELVLDR ALVNYKYKIV IDCKQIQDAR
GDTAKIARAA SQVGYRPVFS WMNSISSFID LAAQGMIGTK AGFSETLDAQ LSNIWQNTAT
ALKKVTLEHR KKNDKDSHLT DEEYLEAHPE LRPVVIIDNY LHNASENSVV YDKITEWAAS
LTAGNIAHVI FLTTDVSYAK PLSKALPNSV FRTITLGDCS LEVGRKFVLN HLAYETKDGN
TQPRRAEELE DLDACIQILG GRVTDLEFMA HRIEAGETPR GAVNRIIEQS ASEILKMFLL
TPETIEQSWT HEQAWYLIKR LAESKDGALS YNEVVLSDLF KENGEITLRA LEHAELISIA
SINGCPQTIR PGKPVLRAAF KQVTENKALS SRMDLAIISQ MINKENKSIG KYEEELSLLG
SLPKQPRELT ARIQWLLNKV YSSQNKIAKY EKESAFLQKI LRSEH
//
