ID A0A397P7S1_9SPHN Unreviewed; 490 AA.
AC A0A397P7S1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cu(I)/Ag(I) efflux system membrane fusion protein {ECO:0000313|EMBL:RIA44109.1};
GN ORFNames=DFR49_2347 {ECO:0000313|EMBL:RIA44109.1};
OS Hephaestia caeni.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Hephaestia.
OX NCBI_TaxID=645617 {ECO:0000313|EMBL:RIA44109.1, ECO:0000313|Proteomes:UP000266568};
RN [1] {ECO:0000313|EMBL:RIA44109.1, ECO:0000313|Proteomes:UP000266568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25527 {ECO:0000313|EMBL:RIA44109.1,
RC ECO:0000313|Proteomes:UP000266568};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIA44109.1}.
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DR EMBL; QXDC01000003; RIA44109.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A397P7S1; -.
DR Proteomes; UP000266568; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.730; -; 1.
DR Gene3D; 2.40.50.320; Copper binding periplasmic protein CusF; 1.
DR InterPro; IPR021647; CusF_Ec.
DR InterPro; IPR042230; CusF_sf.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR045800; HMBD.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30097; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR PANTHER; PTHR30097:SF15; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR Pfam; PF11604; CusF_Ec; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR Pfam; PF19335; HMBD; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000266568}.
FT DOMAIN 51..78
FT /note="Heavy metal binding"
FT /evidence="ECO:0000259|Pfam:PF19335"
FT DOMAIN 111..319
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 471..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 51229 MW; A2CF412303BB56A3 CRC64;
MMTIELSRRA RLGLAAATLA LVAGATGYGI ATLIHPGDMP AAAEGGRKVL YWYDPMVPSQ
HFDKPGKSPF MDMQLVPKYA DEAGGEAGIR IDPARAQNLG IRVVAAERGT LSSALTATGT
IDFNQRDVAI VQARSGGFVS RVYARAPGDV IGAGAPLADL LVPEWAGAQS EYLAVRRTGD
AAMISAARQR LTLLGMPAGT IAAVERGGRP HNIVTLSAPS GGVIKTLGVR AGMTVAAGQT
LAEVNGLGTV WLNAAVPERM AGQLRPGQTA SATLTAYPGE RFAGRIAAIL PSVEAESRTL
TVRIELANRG GRLRPGMFAN VDFGGSERTG LLVPTEAVIR TGRRTLVMLA LSNGRYQPAE
VRIGNESDGQ SEVLAGLSEG EKVVASGQFL LDSEASLSGM EARPIGGMAP ASALTRLYET
SGRIEKIDAN GVTLAHGPVP ALQWPAMTMT FRLGDPALAR GFKAGDRVRF GFDQPPQGPT
LRSMTREAGQ
//
