ID   A0A397PAP2_9SPHN        Unreviewed;       585 AA.
AC   A0A397PAP2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   SubName: Full=Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II {ECO:0000313|EMBL:RIA46636.1};
GN   ORFNames=DFR49_1184 {ECO:0000313|EMBL:RIA46636.1};
OS   Hephaestia caeni.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Hephaestia.
OX   NCBI_TaxID=645617 {ECO:0000313|EMBL:RIA46636.1, ECO:0000313|Proteomes:UP000266568};
RN   [1] {ECO:0000313|EMBL:RIA46636.1, ECO:0000313|Proteomes:UP000266568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25527 {ECO:0000313|EMBL:RIA46636.1,
RC   ECO:0000313|Proteomes:UP000266568};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RIA46636.1}.
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DR   EMBL; QXDC01000002; RIA46636.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A397PAP2; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000266568; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:RIA46636.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266568};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        121..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          64..443
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          493..569
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   585 AA;  62561 MW;  6515C1669131DDD8 CRC64;
     MERCPVDSQP IVALDPAWPA MSIAEAEALL TAPGQKFEME TVTIRGVPTR VWKNSPPHLR
     ALIEAARAYG GLPFTVYEDE RVSYDANFRA IAALAAHLAA LGVGKGDRVA LAMRNLPEWP
     VAFFAVVTLG AIVVPLNAWW TGAELAYGLA DSGAGVLIAD ERRHQCLAAH YADLPGLRHV
     LVTRAAAPLE GAHALEEVIG NPRDYATLPD RPLPAAEIAP DDAAGIFYTS GTTGAPKGAL
     GTHRNMATNI LSGGFAAART CLRRGETPPE PTPRSMLLVI PLFHVTASSA VMMGAIATGS
     TLVFMRKWEP VEAMAIIERE KVTMTGGVPT IAWQLLEHPE RGRFDLSSLE SIAYGGAPAA
     PELVRRIHAE FGALPGSGWG MTETMATVTT HSGEDYLNRP ESCGPPVATA DLKIMDEDGT
     RELPSGEIGE LWAKGPMIVN GYWNNAAATV ATFVDGWVRT GDIARIDEEG FCFIVDRAKD
     IVIRGGENIY SSEVENVLYV HPAVTDCALI GIPHRTLGEE PVAVVHLAPG STASEHELQA
     WVGRHLAAFK VPVAIRFVAE TLPRNANGKI LKRDLKGLFA EEAAA
//