ID A0A397TT83_9GLOM Unreviewed; 653 AA.
AC A0A397TT83;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=C1645_813012 {ECO:0000313|EMBL:RIA98281.1};
OS Glomus cerebriforme.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Glomus.
OX NCBI_TaxID=658196 {ECO:0000313|EMBL:RIA98281.1, ECO:0000313|Proteomes:UP000265703};
RN [1] {ECO:0000313|EMBL:RIA98281.1, ECO:0000313|Proteomes:UP000265703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM 227022 {ECO:0000313|EMBL:RIA98281.1,
RC ECO:0000313|Proteomes:UP000265703};
RA Morin E., San Clemente H., Chen E.C.H., De La Providencia I., Hainaut M.,
RA Kuo A., Kohler A., Murat C., Tang N., Roy S., Loubradou J., Henrissat B.,
RA Grigoriev I.V., Corradi N., Roux C., Martin F.M.;
RT "Comparative genomics reveals the genomic features of Rhizophagus
RT irregularis, R. cerebriforme, R. diaphanum and Gigaspora rosea, and their
RT symbiotic lifestyle signature.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIA98281.1}.
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DR EMBL; QKYT01000018; RIA98281.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A397TT83; -.
DR STRING; 658196.A0A397TT83; -.
DR Proteomes; UP000265703; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000265703};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 625..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..180
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 653 AA; 71529 MW; 24C86CF135BA5B69 CRC64;
MPCVRILNST SVAGCQSLKP ASGILILTET QELLDNFIKS NQAGKYVVVL PYELMTNDNL
RSLESSRKMS GVLALINGTD PSSPTSSPII TRPTNLSPDE KCPNCQFDLY RNDESRYLWN
PNGLGIIQES YDFPIFALYP YDRASNRTYN RIISGVQFNE RRAFERFPLK TVQLESLMFA
AIDAPTCLRR NFCDPIGGHS VYSTPSIDMN ENDGKPIIVV SAAMDSKSLF QDITLGVNNG
ISGSIALIAI ADALSKSQPP VKNFPKHILF TLFAGESWGF LGSQRFVKNI FEPFNCIQNN
TKPTTSCGIN TGNFGGCSFP CFRDLDFKRI NFNNIDSIFE LSSVSNGQTG VQGLNYFVHV
DDENNVGNQV LIQGLRALAV GGTSVKSASE DGVFRKLPPS SSMAFLEKNR NIPAVVISDF
QANLTNYNSE YDDGNGLTDA DFSRITTSIC SIANVTSQAI WLHAQNLLNP ANPAANVPIT
VNCTLVRELL GCLTINGTCS LFDAFSDNND KRISHYTGVF DPTSPALLPL FHYNVLGSIN
ANLTSNRGCQ DDGDCQFGEI CANLNCTNSF TRFHHSYGVG LEFNEKGEAV VVDPEKATWV
ESGWSGDFDF QIFNSTSTGS QIGELLTGIL VTVLSIIGII FGKKYIRKTL KLD
//
