ID A0A397Y9V6_BRACM Unreviewed; 1537 AA.
AC A0A397Y9V6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=BRARA_I04331 {ECO:0000313|EMBL:RID47760.1};
OS Brassica campestris (Field mustard).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3711 {ECO:0000313|EMBL:RID47760.1, ECO:0000313|Proteomes:UP000264353};
RN [1] {ECO:0000313|EMBL:RID47760.1, ECO:0000313|Proteomes:UP000264353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B-3 {ECO:0000313|Proteomes:UP000264353};
RA Bowman J., Kohchi T., Yamato K., Jenkins J., Shu S., Ishizaki K.,
RA Yamaoka S., Nishihama R., Nakamura Y., Berger F., Adam C., Aki S.,
RA Althoff F., Araki T., Arteaga-Vazquez M., Balasubrmanian S., Bauer D.,
RA Boehm C., Briginshaw L., Caballero-Perez J., Catarino B., Chen F.,
RA Chiyoda S., Chovatia M., Davies K., Delmans M., Demura T., Dierschke T.,
RA Dolan L., Dorantes-Acosta A., Eklund D., Florent S., Flores-Sandoval E.,
RA Fujiyama A., Fukuzawa H., Galik B., Grimanelli D., Grimwood J.,
RA Grossniklaus U., Hamada T., Haseloff J., Hetherington A., Higo A.,
RA Hirakawa Y., Hundley H., Ikeda Y., Inoue K., Inoue S., Ishida S., Jia Q.,
RA Kakita M., Kanazawa T., Kawai Y., Kawashima T., Kennedy M., Kinose K.,
RA Kinoshita T., Kohara Y., Koide E., Komatsu K., Kopischke S., Kubo M.,
RA Kyozuka J., Lagercrantz U., Lin S., Lindquist E., Lipzen A., Lu C.,
RA Luna E., Martienssen R., Minamino N., Mizutani M., Mizutani M.,
RA Mochizuki N., Monte I., Mosher R., Nagasaki H., Nakagami H., Naramoto S.,
RA Nishitani K., Ohtani M., Okamoto T., Okumura M., Phillips J., Pollak B.,
RA Reinders A., Roevekamp M., Sano R., Sawa S., Schmid M., Shirakawa M.,
RA Solano R., Spunde A., Suetsugu N., Sugano S., Sugiyama A., Sun R.,
RA Suzuki Y., Takenaka M., Takezawa D., Tomogane H., Tsuzuki M., Ueda T.,
RA Umeda M., Ward J., Watanabe Y., Yazaki K., Yokoyama R., Yoshitake Y.,
RA Yotsui I., Zachgo S., Schmutz J.;
RT "WGS assembly of Brassica rapa FPsc.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
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DR EMBL; CM010636; RID47760.1; -; Genomic_DNA.
DR Proteomes; UP000264353; Chromosome a9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223:SF383; ABC TRANSPORTER C FAMILY MEMBER 14; 1.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 973..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1236..1256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 324..604
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 639..862
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 979..1258
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1295..1529
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 879..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1537 AA; 171226 MW; 9FB406A56E128FF5 CRC64;
MWWLSSSSWV SGLSCSSSGF IEPSSSLPTP IQWLRFILLS PCPQRLLSSA VDLLFLIILT
FFALHKLCSS SSTTTEADIR KPLIARRTVT RTTGLFKTTV VATILLSFCS LALCVLAFTT
RTNLKLVDAL FWLIHAVTYA VIAVLVLHQK RFASSNHPLT LRIYFVSSFI VTTLFTVSGI
LHLISDDPSA ASLRSDDVAS FVSFPLTAVL LIVSIRGSTG IVTTTSNVAI AAKSNDVVLE
KSSENVSLYA SASFLSKTFW IWMNPLLSKG YKSPLNLDQV PTLSPEHRAE KLASLFESKW
PKPQENSRNP VRTTLLRCFW KEVALTAVLA ILRLSVIYVG PVLIQSFVDF TSGKGSSPSE
GYYLVLILLV AKFVEVLSTH QFNFNSQKLG MLIRSTLITA LYKKGLKLTG SARQNHGVGQ
IVNYMAVDAQ QLSDMMLQLH AIWLMPLQVA VALVLLYGVL GPSVVTTVIG LTGIFVFILM
GTRRNNRFQF SLMMNRDSRM KATNEMLNYM RVIKFQAWED HFNERILKFR EMEFGWLSKF
LYSISGNIIV LWSTPVLISA LTFTTAVFLG VKLDAGTVFT TTTIFKILQE PIRTFPQSMI
ALSQAMISLG RLDAYMTSRE LSGETVERVQ GCGEGNVAVE IKDGSFSWDD DDDEPAIENI
NFEVKKGELA AIVGTVGSGK SSLLASVLGE MHKISGKVRV CGNTAYVAQT SWIQNGTVQD
NILFGLPMDS HKYNEVVKVC CLDKDLQMME FGDQTEIGER GINLSGGQKQ RIQLARAVYQ
EADVYLLDDV FSAVDAHTGS DIFKKCVRGA LKGKTVLLVT HQVDFLHNVD CILVMRDGMI
VQSGKYDELV SNGLDFGALV AAHETSMELV EAGSANVPTT SPITQRSISI ESPRQPPTPK
SPKIHRTTSL ESPRIQRTTS MESPRLGELN DEHIKSFLGS NIPEDGSRLI KDEEREVGQV
SFQVYKLYST EAYGWWGMIL VLFFSLAWQG SIMASDYWLA YETSAKNAVS FDPSVFIRVY
LIIAALSIVL VCLRAFYITH LGLKTAQIFF KQILNSLVHA PMSFFDTTPS GRILSRASTD
QTNVDIFIPF MIGLVAAMYT TLLSIFIVTC QYAWPTVFFV IPLAWLNIWY RGYYLASSRE
LTRLDSITKA PVIHHFSESI AGVMTIRSFK KESIFRQENV KRVNANLRMD FHNNGSNEWL
GFRLELIGSW VLCISALFMV MLPSNIIKPE NVGLSLSYGL SLNSVLFWAI YLSCFVENKM
VSVERIKQFT DIPSEATWEI KESRPPPTWP YKGNIRLDDV KVRYRPNTPL VLKGLTIDIK
GGEKVGVVGR TGSGKSTLIQ VLFRLVEPSG GKIIIDGIDI CTLGLHDLRS RFGIIPQEPV
LFEGTVRSNI DPTEKYSDEE IWKSLERCQL KEVVSSKPGK LDSLVADSGE NWSVGQRQLL
CLGRVMLKRC RILFLDEATA SVDSQTDAMI QKIIREDFSS CTIISIAHRI PTVMDCDRVL
VIDAGKAKEY DSPVRLLERR SLFAALVQEY ALRSAGI
//
