ID A0A397ZY54_BRACM Unreviewed; 1086 AA.
AC A0A397ZY54;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Tower domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRARA_C00020 {ECO:0000313|EMBL:RID67816.1};
OS Brassica campestris (Field mustard).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3711 {ECO:0000313|EMBL:RID67816.1, ECO:0000313|Proteomes:UP000264353};
RN [1] {ECO:0000313|EMBL:RID67816.1, ECO:0000313|Proteomes:UP000264353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B-3 {ECO:0000313|Proteomes:UP000264353};
RA Bowman J., Kohchi T., Yamato K., Jenkins J., Shu S., Ishizaki K.,
RA Yamaoka S., Nishihama R., Nakamura Y., Berger F., Adam C., Aki S.,
RA Althoff F., Araki T., Arteaga-Vazquez M., Balasubrmanian S., Bauer D.,
RA Boehm C., Briginshaw L., Caballero-Perez J., Catarino B., Chen F.,
RA Chiyoda S., Chovatia M., Davies K., Delmans M., Demura T., Dierschke T.,
RA Dolan L., Dorantes-Acosta A., Eklund D., Florent S., Flores-Sandoval E.,
RA Fujiyama A., Fukuzawa H., Galik B., Grimanelli D., Grimwood J.,
RA Grossniklaus U., Hamada T., Haseloff J., Hetherington A., Higo A.,
RA Hirakawa Y., Hundley H., Ikeda Y., Inoue K., Inoue S., Ishida S., Jia Q.,
RA Kakita M., Kanazawa T., Kawai Y., Kawashima T., Kennedy M., Kinose K.,
RA Kinoshita T., Kohara Y., Koide E., Komatsu K., Kopischke S., Kubo M.,
RA Kyozuka J., Lagercrantz U., Lin S., Lindquist E., Lipzen A., Lu C.,
RA Luna E., Martienssen R., Minamino N., Mizutani M., Mizutani M.,
RA Mochizuki N., Monte I., Mosher R., Nagasaki H., Nakagami H., Naramoto S.,
RA Nishitani K., Ohtani M., Okamoto T., Okumura M., Phillips J., Pollak B.,
RA Reinders A., Roevekamp M., Sano R., Sawa S., Schmid M., Shirakawa M.,
RA Solano R., Spunde A., Suetsugu N., Sugano S., Sugiyama A., Sun R.,
RA Suzuki Y., Takenaka M., Takezawa D., Tomogane H., Tsuzuki M., Ueda T.,
RA Umeda M., Ward J., Watanabe Y., Yazaki K., Yokoyama R., Yoshitake Y.,
RA Yotsui I., Zachgo S., Schmutz J.;
RT "WGS assembly of Brassica rapa FPsc.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM010630; RID67816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A397ZY54; -.
DR Proteomes; UP000264353; Chromosome a3.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 3.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 480..554
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 558..682
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 371..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 119540 MW; 3ABF8294A1E4C955 CRC64;
MSTWSLLPDS SGDCFRWEVA GRILQSDSED YAIESTAPLP SMNDLLLQDL HNIGGSSLQV
DSAATLPMFR TASGRSVPLK DSSIAKALSI LGTHSDNVPL RESGFGDPNS FFQTASNKKV
FVSSAGLSRA NALLGLEADD FNGFNHVKRS NSSHQKRGCS ELKTHATGVQ HHSEIPGQYE
CHVFEKISDN LYTSAVVPPT MFQTAGGKTL SVSVQALKRA RNLLGDPESG TLFDDVAAGD
QFATPQKVQR LGDTAIKNRN ANTGYNAYEG KTSNKHTATS FVSPLRSSSK QFRSAKLEDL
ASGGNLIKKF DAAVDETDCA LNTTKVATHG VSYNRPLASN MAVNNAKANG FIPIAKQFGQ
PLVDITNRSA NNKQDSTQKK RLGKTISVSP FKRPRNSSFK TPLKKNAQHA LSGLSIVSSD
TLNSKKVLST RYPERSPRVY IKDYFRMHPT VTTKMNYVPD HVRRIKSSNA DKYVFRDESS
SNMVGAETFF QILAESGASL QQASRKWIIN HYRWIVWKLA CYETCYPLIC RGNFLTITNV
LEELKYRYER EVNHGHCSAI KKILSGDAPA SSMMVLYISA IYPKTDNDSQ EALGSGSGSN
VKVELSDGWY SMNAALDVSL TKQLNAGKLF VGQKLRILGA GLSGWATPTS PLEAVISNTI
CLLLNINGTY RAHWADRLGF CKEVGVPLAF NCIKGNGGPV PKTLAGITRI YPILYKERLG
ERKSIIRSER MESRMTELHN QRRSALVEGL MCEYERGVNG VHSQNDTDSE EGAKVFKLLE
TASEPELLMA EMSLEQLTSF TTYKSKFEAA KQIQMEKSVA KALEEAGLSE RDVTPFMRIR
LVGLTSLSYE GEHNPKEGIV TIWNPTERQR TELTEGKIYI VKALVPTISD SETLYLHARG
SSSRWEPLSP KASSSFQPFF NPRKPISLSN FGGIPLSSEF DIAAYVVYVG NVYTDVEQKK
QWVFVTDGST QRSRSGEISN SLLAISFSTP SMDDLPTPHI SHSLVGSVVG FCNLIKRAKD
AKNDMWVGEA TENSVYSINA EAAYSSHLKT SSSHIQTWAK LSSSNSVTYK LRQRVLFIIG
ASTCSR
//
