ID A0A398CQH8_9BACL Unreviewed; 549 AA.
AC A0A398CQH8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:RIE04783.1};
GN ORFNames=D3H35_04715 {ECO:0000313|EMBL:RIE04783.1};
OS Cohnella faecalis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=2315694 {ECO:0000313|EMBL:RIE04783.1, ECO:0000313|Proteomes:UP000266340};
RN [1] {ECO:0000313|EMBL:RIE04783.1, ECO:0000313|Proteomes:UP000266340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K2E09-144 {ECO:0000313|EMBL:RIE04783.1,
RC ECO:0000313|Proteomes:UP000266340};
RA Zhu H.;
RT "Cohnella cavernae sp. nov., isolated from a karst cave.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIE04783.1}.
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DR EMBL; QXJM01000023; RIE04783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A398CQH8; -.
DR OrthoDB; 9788659at2; -.
DR Proteomes; UP000266340; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR43671:SF13; LD04361P; 1.
DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:RIE04783.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000266340};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:RIE04783.1};
KW Transferase {ECO:0000313|EMBL:RIE04783.1}.
FT DOMAIN 18..264
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 549 AA; 60458 MW; 00846EE3CC24B278 CRC64;
MSGKTLLVEP GAIFANRYRV VEPIGQGGMG RVYMAEDLRL EGRLRALKLI ATLPEEREAF
IREARMLCRL THPNIPEIVD YYSPNEDGVA AIVMDYIAGD TLAQRFDKFG RKLSFGQVLQ
MTIQLCEVLQ YLHGQAPAIV YRDLKPSNVI IDSRDRAVLV DFGIARWHRP NAVSDTLQLG
TPGFASPEQL LGKQSDERSD LYGLGALVYF LLTGGFFAIR RNRHSEKFVV EAVPRAFREM
VELLLSEDPS HRPKSAASVL EHLLNIRELG ASGEGSFRFD ASKGGGNSFI KRDVTIAAVL
SAYPGAGATF VTLALSSALS IAGVDHAVVE CPGGEAEMYG LLDGARKMPA RAQFANGACQ
RVAGPIWREG RASYVPLDPF RAAQAQCHCV LDESFVSFLQ KLGAPLVLLD VSSRWEHPDA
KEWIGNIADS IIWVADCYPS KWSLKRQQEG ASLYQAIEGR QAAAIWIANR DHSFAERKEW
LSMFPVAPLT ALPRFSEDAV LKAIWDGAGV PSAKKDKELY FRSLKTVLKR IVPAGVAKDV
LTANTAYFS
//
