ID A0A398CRJ2_9BACL Unreviewed; 516 AA.
AC A0A398CRJ2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN Name=cobA {ECO:0000313|EMBL:RIE03889.1};
GN ORFNames=D3H35_07930 {ECO:0000313|EMBL:RIE03889.1};
OS Cohnella faecalis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=2315694 {ECO:0000313|EMBL:RIE03889.1, ECO:0000313|Proteomes:UP000266340};
RN [1] {ECO:0000313|EMBL:RIE03889.1, ECO:0000313|Proteomes:UP000266340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K2E09-144 {ECO:0000313|EMBL:RIE03889.1,
RC ECO:0000313|Proteomes:UP000266340};
RA Zhu H.;
RT "Cohnella cavernae sp. nov., isolated from a karst cave.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIE03889.1}.
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DR EMBL; QXJM01000029; RIE03889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A398CRJ2; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000266340; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000266340};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 5..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 268..503
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 516 AA; 56346 MW; 8B9D433F118599FF CRC64;
MAKGKVYLVG AGPGDPKLIT VRGLEALRKS DCIVYDRLAG PQLLAEARPD AERIYVGKLP
DRHTMKQEDI NRLLVDLALQ GKTVTRLKGG DPTVFGRVGE EAELLKQNGV AFEIVPGITS
AISVPAYAGI PVTHRDLASS FSIITGHESP DKLDRSIHWD KVTNATGTLV FLMGVAKVGY
ISEQLVKHGR SPETPIALVR WGTRAEQRTI VGTLANIEDK VKEAGFKPPA VIIVGDVVRQ
RETLAWVEDK PLFGMRILVT RARSQASELT NRIDELGGEP YEFPVIETRA VSSETAVQAV
RDALLRSETY DWVVLTSVNG VDYFFRWLDE CSRDIRDFHR AKFAAVGPKT AEALRIRGVR
AAVLPDKFHA EGLLDSLAEE LLPGQKALLP HGDLARDVLV RELAGRGVET VGIDVYETTL
AVNNDPFLPE MLRDGDIHAI TFTSSSTVTN LLEALRRLGA EDPAAWLKGI DIVCIGPITA
RTAEENGLQV TVTAEHSTIE GLIDALAANR RSKERG
//
