ID A0A399F325_9DEIN Unreviewed; 625 AA.
AC A0A399F325;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:RIH89252.1};
DE EC=3.7.1.22 {ECO:0000313|EMBL:RIH89252.1};
GN Name=iolD {ECO:0000313|EMBL:RIH89252.1};
GN ORFNames=Mrose_00392 {ECO:0000313|EMBL:RIH89252.1};
OS Calidithermus roseus.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Calidithermus.
OX NCBI_TaxID=1644118 {ECO:0000313|EMBL:RIH89252.1, ECO:0000313|Proteomes:UP000265341};
RN [1] {ECO:0000313|EMBL:RIH89252.1, ECO:0000313|Proteomes:UP000265341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110900 {ECO:0000313|EMBL:RIH89252.1,
RC ECO:0000313|Proteomes:UP000265341};
RA Da Costa M.S., Albuquerque L., Raposo P., Froufe H.J.C., Barroso C.S.,
RA Egas C.;
RT "Meiothermus roseus NBRC 110900 genome sequencing project.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIH89252.1}.
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DR EMBL; QWLA01000004; RIH89252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A399F325; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000265341; Unassembled WGS sequence.
DR GO; GO:0102481; F:3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RIH89252.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265341};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 7..132
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 223..355
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 420..579
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 625 AA; 68075 MW; 0F3D061731AC9BCC CRC64;
MSTQRLTVAQ ALVKFLAAQH SERDGRRMRL IAGVWAIFGH GNVSGLGQAL EEYGDEVGLP
TYRPQNEQAM VHTAAAYAKH TSRMSTFACT ASVGPGSLNM ITAAAGATIN RLPVLLLPSD
YFANRLPDPV LQQLEHPLEH DVSVNDAFRP VSRFFTRITR PSQLLSALPE AMRVLTDPAE
TGAVTICLPE DVQTEAYDWP EGFFAPRVWR IRRPAPEPEV VGQVAELIKE AKRPLIVTGG
GTLYSEAHAQ LAAFAQTYGI PVAESQGGKG ALPWDHPMCV GAVGSNGGTA ANRLAKEADL
VLAIGTRLGD FVTASKTAFQ NPQVKFVGVN VLPFDAGKLN GLSLVADARR ALEALDQALK
GFVGTAPSYR EEVARLKKEW DELVQGYRTP KSEKKEMAQA EVIGLTNETF GGKVTVICAA
GSLPGDLLKL WRCEDPKAYH LEYGFSCMGY EIPAGLGVAM AEPGREVVVF VGDGTYLMMN
SEIVTAVAEG LGFTVMLIDN KAFGSIRGLQ MSLGSPSFNN ELRRRDDRTG RTDGAPLEVD
FAAHARAMGA SVWSPKNYRE LEEALKQARK ARGVRVIVVP VSIDDRVPAF ESWWDVPVAE
VSGQPEVRKA REEYEAYLKK QRRYF
//