ID A0A399F8A3_9DEIN Unreviewed; 609 AA.
AC A0A399F8A3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Putative multidrug resistance protein EmrK {ECO:0000313|EMBL:RIH92897.1};
GN Name=emrK {ECO:0000313|EMBL:RIH92897.1};
GN ORFNames=Mgrana_01172 {ECO:0000313|EMBL:RIH92897.1};
OS Meiothermus granaticius NBRC 107808.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX NCBI_TaxID=1227551 {ECO:0000313|EMBL:RIH92897.1, ECO:0000313|Proteomes:UP000266178};
RN [1] {ECO:0000313|EMBL:RIH92897.1, ECO:0000313|Proteomes:UP000266178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF-68 {ECO:0000313|EMBL:RIH92897.1,
RC ECO:0000313|Proteomes:UP000266178};
RA Da Costa M.S., Albuquerque L., Raposo P., Froufe H.J.C., Barroso C.S.,
RA Egas C.;
RT "Meiothermus granaticius genome AF-68 sequencing project.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIH92897.1}.
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DR EMBL; QWLB01000012; RIH92897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A399F8A3; -.
DR Proteomes; UP000266178; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 2.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000266178};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..106
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 293..522
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 63435 MW; D056595FDAD8493B CRC64;
MSENANSQAA AQPPQTTPQP PAATQRPPLR RRFVVFAVLA LMVLGAAGIV FYYVYEGSHF
VNTDNARVAA NTAQVTPQIP GRILDWSVGV GSVVQAGQII GRLDTDTVAQ SNAVNLNSLS
QVAPLTASRA LVRAPISGRI IQSNALVGQL VSAGQSLAVV ADTSSAYISA NVKETQIGRV
KLGQRVTVRL DASGRSFQGR VQEIGQATAS TFSILPNSNA DTGNFTKVVQ VVPVKIYPVE
KPPVELLPGM SASVKITLGD PPLNPIAVKT VKADERPLSL SLSLVGTLTA GSTLNIIPQL
SGTATYVGAD VGQAVKKGQV LLRLDDSTLR TQLEQAQAAL LQAQNTVRQS KANLDLAAST
LDRIRALYQV GGASRQDLNN AQTQFTNAQV AYQTASTAAL QAAQSQVQNL QLQLAKTVIT
SPVDGTLASR SVNVGEVVAP GQSVMSIVDA GPLKLMATLP GSETDLIKVG QAVRVSADAL
PGESFEGKIS AVGPASIATG QFFPLEVRVF DPQGRLRVGM IATGTLQVQY RPVVPVVPLS
AIAQIGNQNY VYRVVEGKAV RTPVQLGLSG KDASGTPYQV ITGGLELGTP VIVSPVGALW
DGATVSEGS
//
