ID A0A399G050_9ACTN Unreviewed; 397 AA.
AC A0A399G050;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RII01965.1};
GN ORFNames=NI17_014850 {ECO:0000313|EMBL:UOE18123.1}, NI17_14385
GN {ECO:0000313|EMBL:RII01965.1};
OS Thermobifida halotolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Thermobifida.
OX NCBI_TaxID=483545 {ECO:0000313|EMBL:RII01965.1};
RN [1] {ECO:0000313|EMBL:RII01965.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44931 {ECO:0000313|EMBL:RII01965.1};
RA Toth A., Tancsics T.A., Farkas T., Papp P., Olasz F., Balint B.,
RA Herczeg R., Nagy I., Baka E., Kukolya J.;
RT "De novo genome project of the cellulose decomposer Thermobifida
RT halotolerans type strain.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:UOE18123.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 44931 {ECO:0000313|EMBL:UOE18123.1};
RA Nagy I., Horvath B., Kukolya J., Nagy I., Orsini M.;
RT "De novo genome project of the cellulose decomposer Thermobifida
RT halotolerans type strain.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; JRUV01000260; RII01965.1; -; Genomic_DNA.
DR EMBL; CP063196; UOE18123.1; -; Genomic_DNA.
DR RefSeq; WP_068692286.1; NZ_LIZN01000012.1.
DR AlphaFoldDB; A0A399G050; -.
DR STRING; 483545.GCA_001660385_01028; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000265719; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265719}.
FT DOMAIN 7..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..284
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 315..366
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 397 AA; 41872 MW; 0F7D45CFE78038A7 CRC64;
MVEEFSKVGV VGLGTMGAGI VEVFAGAGFA VTGVEVNDAA LERGRGHLEK SLAKAVAKGK
LTEDERRDIL GRVTFTTSRE DLADADFAVE AVPERMDVKR SVFTDLDRIL PSGSILATNT
SSLSVTEIAA LTNRPGKVIG LHFFNPAPVM KLVEIVGTVV TDPGVLDVAT EVVKRLGKTP
VAVTDRAGFV ANALLVPYLN DAVTVYERGL ATREQIDAAV TEAAGFPMGP LTLMDLVGLD
VLLDVMDVLW EEFRRPRYAA APLLRRMVAA GLLGRKSGRG FYDYSVSTPA EQEPTGPLAA
LVGDGAGQVD LAGLLLAPHI NDAAHMIGDG YATADDVDTA MRLGCGYPRG LAEMLDERGV
KNVTGTLADL AGLGLFTDDV APLLTLLAAR GRDTLRD
//
