ID   A0A399G1N6_9ACTN        Unreviewed;       579 AA.
AC   A0A399G1N6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Serine protease {ECO:0000313|EMBL:RII01432.1};
DE   SubName: Full=Trypsin-like peptidase domain-containing protein {ECO:0000313|EMBL:UOE19424.1};
GN   ORFNames=NI17_022320 {ECO:0000313|EMBL:UOE19424.1}, NI17_17980
GN   {ECO:0000313|EMBL:RII01432.1};
OS   Thermobifida halotolerans.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Thermobifida.
OX   NCBI_TaxID=483545 {ECO:0000313|EMBL:RII01432.1};
RN   [1] {ECO:0000313|EMBL:RII01432.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44931 {ECO:0000313|EMBL:RII01432.1};
RA   Toth A., Tancsics T.A., Farkas T., Papp P., Olasz F., Balint B.,
RA   Herczeg R., Nagy I., Baka E., Kukolya J.;
RT   "De novo genome project of the cellulose decomposer Thermobifida
RT   halotolerans type strain.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:UOE19424.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 44931 {ECO:0000313|EMBL:UOE19424.1};
RA   Nagy I., Horvath B., Kukolya J., Nagy I., Orsini M.;
RT   "De novo genome project of the cellulose decomposer Thermobifida
RT   halotolerans type strain.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; JRUV01000281; RII01432.1; -; Genomic_DNA.
DR   EMBL; CP063196; UOE19424.1; -; Genomic_DNA.
DR   RefSeq; WP_068690344.1; NZ_LIZN01000005.1.
DR   AlphaFoldDB; A0A399G1N6; -.
DR   STRING; 483545.GCA_001660385_04295; -.
DR   OrthoDB; 9758917at2; -.
DR   Proteomes; UP000265719; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR   PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:RII01432.1};
KW   Protease {ECO:0000313|EMBL:RII01432.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265719}.
FT   DOMAIN          461..560
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   REGION          1..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  57674 MW;  30B2A0991CF45439 CRC64;
     MSAIDRGSGS SMEEPERPVG PQADADGREN VTDTGAGEAS GSTARSEVPP SSSDAAPAAD
     PHPGQQRETP EVRRSEVPLR PARHQGPFAP GHTAHQPGPG QHAPGQPGPD QSASGPPPSG
     QHPSGPFGSG QHASGPHSSG PHAPAPSSEW ARQPEWFERA TAHQVQGHQQ HTGGWATPSP
     RGAFSSHGGG FPPPPHDAPA MPGAAPPETG QRRRGRVVLV AAATALLTSL VVGPAASVAT
     AYLVDGETTN STSSTSAATG DVSRVADKAL PSVVSISTAE GGGSGFIISS DGLIVTNNHV
     VSGTGEVTVA FNDGSQAEAT TVGTDPVSDL AVIQAEGVSG LTPATLGDSD QVAVGARVVA
     IGAPLGLSGT VTSGVISALE RPVNTGVSGQ QPDSPFTLPP EGEQDEPQAT TSTVIDAIQT
     DAPINPGNSG GPLMNMDGEV IGINTAIATT SGGGLTQSGS IGLGFAIPIN QAKPTIDELV
     TTGEATYAAI EAAVTVAEDG SGAELVDVTR GGAADQAGLQ AGDVIVGVGN RAVTDPNVLI
     AEIRSHRPGD TVTVTYERDG RTAEAQVTLS AQSSSDIGN
//