ID   A0A3A1U1P2_9MICO        Unreviewed;       435 AA.
AC   A0A3A1U1P2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase {ECO:0000313|EMBL:RIX30431.1};
GN   ORFNames=D1781_03095 {ECO:0000313|EMBL:RIX30431.1};
OS   Amnibacterium setariae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Amnibacterium.
OX   NCBI_TaxID=2306585 {ECO:0000313|EMBL:RIX30431.1, ECO:0000313|Proteomes:UP000265742};
RN   [1] {ECO:0000313|Proteomes:UP000265742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DD4a {ECO:0000313|Proteomes:UP000265742};
RA   Kim I.;
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RIX30431.1}.
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DR   EMBL; QXTG01000001; RIX30431.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A1U1P2; -.
DR   OrthoDB; 9780685at2; -.
DR   Proteomes; UP000265742; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265742};
KW   Transferase {ECO:0000313|EMBL:RIX30431.1}.
FT   MOD_RES         211
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   435 AA;  45856 MW;  160EF8D929B6F36F CRC64;
     MSDEDWGFDT AQVHAGAAPD PGTRARATPI FATSSFVYDS AEQAAAQFLL DDVEGFGYTR
     MGNPTTAVAE RRIAALEGGA DAVATASGQS ATALALLNLL RSGDHIVMAS QIYGGTTNLL
     VQRFAEIGIT TTAVPVGDLD AWRAAVRPST RAFFVESIGN PTGAVADLPA LAAVAHDEAR
     VPLVVDNTLA TPYLLRPLEH GADVVVHSTT KFLSGHGTVI GGVVVDGATF DFGAEPERWP
     GFHVPDAGHG TEGYWARFSP QRQAYSRRLR STVLRDYGPA PSPFNSFMLI QGLETLSLRM
     RQHVANAEAV VAHLRSHPQV LSVHHPSVPG TPFAEVAQRL LPRGGGAIVS FDIDGGLDAG
     RRFVDGVRLF SHLANVGDVR SLVIHPASTT NSSQPTEQLA AAGIGPGLIR LSVGIEDPAD
     LIRDLDRAFL AAQSG
//