ID A0A3A1U1Q9_9MICO Unreviewed; 769 AA.
AC A0A3A1U1Q9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=D1781_02870 {ECO:0000313|EMBL:RIX30392.1};
OS Amnibacterium setariae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Amnibacterium.
OX NCBI_TaxID=2306585 {ECO:0000313|EMBL:RIX30392.1, ECO:0000313|Proteomes:UP000265742};
RN [1] {ECO:0000313|Proteomes:UP000265742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD4a {ECO:0000313|Proteomes:UP000265742};
RA Kim I.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIX30392.1}.
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DR EMBL; QXTG01000001; RIX30392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A1U1Q9; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000265742; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000265742}.
FT DOMAIN 18..304
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 305..585
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 769 AA; 84368 MW; EFF5144677D3F351 CRC64;
MTQLVQPMSV EGSSALLEGL NPRQREAVLY RGPALLIVAG AGSGKTSVLT RRIASLLETR
EAWPSQVLAI TFTNKAAGEM RERVRHLVGH AADGMWISTF HSACVRILRR EAEVFGYASG
FTIYDSGDQR ALLKRIVKQY EADVMGLSVA NVGARISKLK NELIDAESFS RDVNLADPKE
ALFLTIFREY TRTLQAANAF DFDDLIAQTV YLFRAFPHVA EPYRRRFRHI LVDEYQDTNH
AQYALIRELT KPAPGVPAAS LTVVGDSDQS IYAFRGADIR NIIEFEQDFP EATVVLLEQN
YRSTQTILDA ANAVIANNFD RKPKNLFTAG GAGDKIVGFT GYSGHDEAQF VADEIEQLHR
NGMEYREIAV FYRTNAQTRA LEEILIRSAV PYRILGGTKF YERAEIKDAM AYLISVANPA
DALAVRRILN TPKRGIGPAT ETQLANFAER NGVTFREALR HAAELGFGPK VTKAITALSD
LLDEATAMTV PPAEGNAPIP VFDVLALLMQ KSGYVDALRA SKDPQDEARM ENIEELLAVT
KEFQRNNPDG LLIDFLTETA LVAAADELDD TSGTVSLMTL HTAKGLEFRA VFLTGIEEDL
LPHRMSVNEP GGPSEERRLF YVGITRARER LYLSLAMTRN SYGETSVSAP SRFLAEIPGE
LIDWRQSPGM TGPGAGGRAA GSLGWSSGGV GAGAGQAKPK TEWTNRVTGK VRDNGDLELA
IGDRVRHDDF GEGRVQAITG TAAKRIAEVQ FDTAGRKRLL VKVAPIVKL
//
