ID A0A3A1USX9_9BACL Unreviewed; 517 AA.
AC A0A3A1USX9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN Name=cobA {ECO:0000313|EMBL:RIX50531.1};
GN ORFNames=D3P08_19825 {ECO:0000313|EMBL:RIX50531.1};
OS Paenibacillus nanensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=393251 {ECO:0000313|EMBL:RIX50531.1, ECO:0000313|Proteomes:UP000266482};
RN [1] {ECO:0000313|EMBL:RIX50531.1, ECO:0000313|Proteomes:UP000266482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22867 {ECO:0000313|EMBL:RIX50531.1,
RC ECO:0000313|Proteomes:UP000266482};
RA Jurado V., Gutierrez-Patricio S., Gonzalez-Pimentel J.L., Miller A.Z.,
RA Laiz L., Saiz-Jimenez C.;
RT "Paenibacillus aracenensis nov. sp. isolated from a cave in southern
RT Spain.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIX50531.1}.
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DR EMBL; QXQA01000014; RIX50531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A1USX9; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000266482; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000266482};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 5..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 267..503
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 517 AA; 56747 MW; B338706BCCB77EE0 CRC64;
MNKGKVYLVG AGPGDPKLMT LRGLECLKAA DVVVYDRLAS PRLLRHVKQG AELVYVGKLP
DRHTMKQEEI NQLLVDLALA GKTVTRLKGG DPTIFGRVGE EAELLYDNGI EFEIVPGITS
AIAVPAYAGI PVTHRDLASS LSIITGHESP DKLDRSIHWD KVTNATGTLL FLMGVAKIGY
IADQLIKHGK PPETPVALVR WGTRVEQETV VGTLATIEQI VREANFQPPA VIVVGEVVLQ
REKLRWYENK PLFGMRILVT RARAQASELA DSIEALGGEP CEFPVIDIRE PSDADAVEKI
RLRLEEAESY QWLMFTSVNG VEYFFRFLRK FGIDIRRFHA ARIAAVGPKT AEALIAKGLI
VEELPVKFHA ESLLEKLEGM VEPGTRALLP RGDLAREVLP KELAAKGVEA VEIDVYETVL
AETQDDLALA YIREGGIHMV TFTSSSTVTN LLELMRRKGA ADPVKLLEGI PIASIGPITT
KTIVDAGLEV TVEAEASTLD SLIDAIMKYN LERRLKS
//
