ID   A0A3A2Z9H0_9EURO        Unreviewed;       829 AA.
AC   A0A3A2Z9H0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   03-MAY-2023, entry version 12.
DE   RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN   ORFNames=PHISCL_08789 {ECO:0000313|EMBL:RJE18873.1};
OS   Aspergillus sclerotialis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Polypaecilum.
OX   NCBI_TaxID=2070753 {ECO:0000313|EMBL:RJE18873.1, ECO:0000313|Proteomes:UP000266188};
RN   [1] {ECO:0000313|Proteomes:UP000266188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 366.77 {ECO:0000313|Proteomes:UP000266188};
RA   Tafer H., Lopandic K.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC       biogenesis, stability and to maintain vacuole morphology.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- SIMILARITY: Belongs to the VPS16 family.
CC       {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJE18873.1}.
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DR   EMBL; MVGC01000480; RJE18873.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A2Z9H0; -.
DR   STRING; 2070753.A0A3A2Z9H0; -.
DR   Proteomes; UP000266188; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR   Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR   PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266188};
KW   Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT   DOMAIN          7..409
FT                   /note="Vps16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04841"
FT   DOMAIN          503..810
FT                   /note="Vps16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
SQ   SEQUENCE   829 AA;  93408 MW;  1A6CA4ECB23C9DC5 CRC64;
     MAASNPLANW EKVGDSFYRK IPVYDAIFDE DVELENYIVA GAPYGGAIAL LRDESKLYRY
     QASPSSRSNI DIYSCSGKCI SRINWERGAV RGLGWSDKEE LLVVSEDGTV CRYFGLHGDF
     TSFSLGNGAE EYGVRDCRFW SSGFVALLSN NQLIAVSKYD EPRPKLLAPS PEGEVSSWSL
     IPPTYTLSRS VEVLLAVDKT VYLIDPSEAE DKVLQNGPFK HVSVSPTGRF VALFTGEGRI
     WVVSSDFQSK FSEYDPKVRT PPRSVEWCGD DAVILAWEDE IHLVGPNGVA TRYFYDGRVH
     VIPELDGVRL LTNDTCEFLH KVASGTEEIF RIGSTSPASV LLDSVDLLEK KSPKADENIQ
     HIRPSLPEAV DTCVKAAGHE FDIYWQKRLL KAASFGKAVL DLYNSDDFVE MTEKLRVLKA
     IRDYQVGLPI SYEQFIRLTP EKLIERLVNR HEYLLAIRIS EYLQIPADKV YVHWASQKVK
     VSNVDDEAVC KLIVQRLDGK PGISFELIAQ AAFDEGRSRL ATQLLNHEPR AGKQVPLLLS
     MEEDEIALDK AIESGDDDLV YYVLLHLKRK LPLASFFRMI NTRPMASALV ETSAQGHDTE
     LLKDLFYQDD RPIDGSNVLL SEALSETDLQ RKPEKLHLAS RLLSDSKDPT VVLQQKMLSE
     ASHLLKVQES LDKDIADRTE FLGLSLNETV YRLVKTGYGK RALKIQSEFK MPEKTFWWLR
     LRALVAKRDW GELEEISKNK KSPVGWEPFY NEILGAGNTK LASVFVPKCT NLPVDTRIEM
     WVKCGMIVKA GEEALKTKDV NTLELLRARA SGPAVAQIER MINQLRPRR
//