ID   A0A3A2ZS77_9EURO        Unreviewed;      1578 AA.
AC   A0A3A2ZS77;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Guanine nucleotide exchange factor {ECO:0000313|EMBL:RJE24247.1};
GN   ORFNames=PHISCL_03407 {ECO:0000313|EMBL:RJE24247.1};
OS   Aspergillus sclerotialis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Polypaecilum.
OX   NCBI_TaxID=2070753 {ECO:0000313|EMBL:RJE24247.1, ECO:0000313|Proteomes:UP000266188};
RN   [1] {ECO:0000313|Proteomes:UP000266188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 366.77 {ECO:0000313|Proteomes:UP000266188};
RA   Tafer H., Lopandic K.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJE24247.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MVGC01000088; RJE24247.1; -; Genomic_DNA.
DR   STRING; 2070753.A0A3A2ZS77; -.
DR   Proteomes; UP000266188; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000266188}.
FT   DOMAIN          607..797
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          49..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1525..1578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1529..1546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1578 AA;  174221 MW;  71D5697DB5839A55 CRC64;
     MSTSSLPIAV DPVALVTTEC ITVTSAMRKH GRWAHSSVSA ILGGNGVSRV YDRDTSAPPS
     PRNGTPRLKP RLPAVDDDHA LANRWGLRGK KGKSMQDNPL ISAFTRLRSD LKGCKDIRTF
     DTPALLHPFL QVIRSSSTSA AITSLALVAI TKFFSYNIIN RDSPRLLMAM QLLSAAITHC
     RFEASDSSAD EIVLLRILKL MEGILSRPEG ELLGDESVCE MMETGLSMCC QGRLSEVLRR
     SAEMAMVNMC QVIFTRLTRL EYAVSSDSDP SKVNQAESEP SKYKMDPSVD GDTVASQHPS
     VMGSDTAGPE REQTSTEGSP ELGVNGSAVT APPNPQDDLS DEVQPYSIPS IRELFRVLID
     LLDPHNRQHT DPMRVMALRI IDVALEVAGP SIARHPSLAA LAEDDLCRHL FQLVRSENIT
     ILTGSLRVAG TLLLTCRSVL KLQQELYLSY LVACLHPRVE IPRESGIDPA LYDGVPQAPK
     LVKPPPSQTS SGRSTPVQVK DRQKLGLEGG TRKPETREAM VESIGVLSRI PSFMVELFVN
     YDCEADRADL CEDMVGLLSR NAFPDSATWS TTNVPPLCLD ALLGYVQFIY DRLDDEPNYE
     GFPDRERLRS QRRIKKIIIK GAQKFNEDPK AGIAYLAAHG IIENPDDPIQ VARFLRGSSR
     VSKKVLGDYI SKRSNENLLD AYVDLFDFSG QSVVEALREF LGAFRLPGEA PLIERIVTTF
     SEKFMDKAHP EGVADKDSLF VLTYGIILLN TDLYNPNVKS QNRMSYTDFA KNLRGVNAGG
     DFAPEFLQEI YDSIKQNEII LPDEHENKHA FDYAWRELLM KTSSTSELVI GETNIYDAEM
     FEATWRPVVA TLSYVFMSAS DDAVYSRVVM GFDQCAQIAA KYGLSEAFDR IIFCLASIST
     LATDKPPGTS LNTEVQAGKK TVMVSELAVK FGRDFRAQLA TVVLFSVLAG NETVVRNSWK
     YVVRILSSLF INSLVPPFDS TLNTELDISP IPLQPPSQVV DRDGRGNDTG LLSAFTSYLS
     SYAADDPPEP SDEELDNTLC TVDCVAACPI DDILSNIKSL PTSSVTLLVE SLLDQLPEET
     APAVIVVKPE RPSNSSRLAN GKPDPNGPTY DPGMIYILEL ATIITLRDRE TLERLGESLS
     IALQTFIRDA RNVHPLALSR IVHYLLALLR VGHDHSFMRV PVILHSISGF DQDILESVSL
     STVKGLSRCI KDTTLLRNEI TISPDFWSIL QRLHQHEEAA PQVFELLQTI AESTPQIITA
     DNYEAAISLA NDFVTAASVG SIEERQRDVI ARRSKGVKQP KPSENQVVNR GVKAIGLIYH
     LTGRAPLLIK QSHLEATEAW SAYWSPIFQS LAAQCVNPCR DIRHHAISTL QRSLLSVQLV
     SSDENEWTAI FDQVLFPLIQ RLLKPETYHS DPLGMSETRV QAATLLCKIF LRYLDQHPNK
     EGMLSLWLKI LDILDRMMNS GQGDSLEEAI PESLKNILLL MANGGYLVPP SQDPSKEEIW
     TETQKRLERF LPDLFKEIFP DVLNEKPQQQ PAAAVSSPNP SSSKENPVDE PSKEPETPAE
     PSAADTPLAT GDGGDNGA
//