ID A0A3A3FRF4_9BURK Unreviewed; 754 AA.
AC A0A3A3FRF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:RJF98792.1};
GN ORFNames=D3871_09895 {ECO:0000313|EMBL:RJF98792.1};
OS Noviherbaspirillum saxi.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Noviherbaspirillum.
OX NCBI_TaxID=2320863 {ECO:0000313|EMBL:RJF98792.1, ECO:0000313|Proteomes:UP000265955};
RN [1] {ECO:0000313|Proteomes:UP000265955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K1R23-30 {ECO:0000313|Proteomes:UP000265955};
RA Zhu H.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJF98792.1}.
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DR EMBL; QYUO01000001; RJF98792.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A3FRF4; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000265955; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RJF98792.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265955}.
FT DOMAIN 416..477
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 683..754
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 754 AA; 83869 MW; DAB97F39D4CA4213 CRC64;
MVSTVASPSE THVQLCVGLN ADDGARVLDA LAFVEPLYRG KTVVTGQDAF AFAEGVATTL
ALLNTDTDSR IAGLLFELAE FDPAAALTIE ERFGEEISEL VNGIHQLMKL HGQTFRHKEV
MRGKNASQQA AEQLETLRKM LLAMASDMRV VLVRLASRVT SLRYFAEIRL EDEKTHGYAR
ETLDLYAPLA NRLGVWQLKW ELEDLAFRFL EPPAYKRIAK MLEEKRLERE SFVASAIARL
SSELAAAGIK ADVFGRPKHI YSIWNKMRGK SLDFSELYDV RAFRVIVDDA KTCYTVLGLV
HNIWTPIPAE FDDYISRPKS NGYQSLHTVV VGEDGRALEV QIRTHEMHRF AEYGVAAHWR
YKESGGSGFA AQKYDEKIAW LRQLLAWKSE VADAVVEQDD IQREWVEKLK SASLDDRIYV
LTPQARVIEL PNGATPIDFA YHLHTDLGHR CRGARVDGAM VPLNTPLKNG QTVEIISARG
GAATAAGPSR DWLSPGYVAS PRTRSKVRAW FNAIEQQETL SHGRALVEKT LQREGRTAIN
HEELAHKLGF AKVDELFLAV GKEEFSLRNI ELLLHADDPH KHPPKQAPDV ETVITNKSRA
SSVAKGARSG VLVVGTDGLL TQLARCCKPA PPDEIVGFVT RGKGISIHRA NCKNLAQIRK
NALERVIQTT WGEPGKETVY PVDIFILASD RQGLLRDVSE IFSREKINVI GVSTQSAKGQ
ARMSFTAEIS STAQLQRALG IIREVSGVLE VQRQ
//