ID A0A3A4AWA2_9ACTN Unreviewed; 534 AA.
AC A0A3A4AWA2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:RJL34165.1};
GN ORFNames=D5H75_06715 {ECO:0000313|EMBL:RJL34165.1};
OS Bailinhaonella thermotolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Bailinhaonella.
OX NCBI_TaxID=1070861 {ECO:0000313|EMBL:RJL34165.1, ECO:0000313|Proteomes:UP000265768};
RN [1] {ECO:0000313|EMBL:RJL34165.1, ECO:0000313|Proteomes:UP000265768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 75507 {ECO:0000313|EMBL:RJL34165.1,
RC ECO:0000313|Proteomes:UP000265768};
RA Tang S., Feng Y.;
RT "YIM 75507 draft genome.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJL34165.1}.
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DR EMBL; QZEY01000002; RJL34165.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A4AWA2; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000265768; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:RJL34165.1};
KW Hydrolase {ECO:0000313|EMBL:RJL34165.1};
KW Nuclease {ECO:0000313|EMBL:RJL34165.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265768}.
FT DOMAIN 304..493
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 534 AA; 56765 MW; E3A9215E8D446144 CRC64;
MRVAISAGEG GAGRIQRLAE DGTPLGPPEE AADLAATVRA IEAAERPRWV WADTTRVYPG
LLASGVRLAR CHDVALVEAI ALAHEGRYGE PSSPGAAWAR LNGLPVPEER AETPEPQASL
FEPEPPAFDE LEAAVAVHAA QLRRLPGPLP LLAAAESAGG LVAAEMTADG LPFRVDVHDE
LLTSLIGPRP AHGMRPKGLQ ELADRIAAAF GRAVNPDSPA QIVKAFAAIG HPVPSTRSHV
LKQVDHPVVP LLLRYKELSR LHTAHGWAWA DQWVSGGRFR PEYVVGGVVS GRWATRGGGA
LQIPKIIRRA VIADPGWKLV VADAAQLEPR VLAALSGDRG LADAAGTTDL YAALADAFGG
HRDRAKIALL SAMYGGGSGE ALQLLAVMRK RFPAAYAYVE DAARAGEDGR LVRSRLGRTC
PPPSARWREL VSGPEGSRAA RDRGRFTRNF VVQATAAEWA LALLAALRRR LPDPARLVFF
QHDEVVVHCP AGLSAEVAAA VHDAAEESRA LLFGDTPVRF PIEAVPVDSY ADAK
//
