ID A0A3A4B1R2_9ACTN Unreviewed; 430 AA.
AC A0A3A4B1R2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Multidrug efflux pump Tap {ECO:0000256|ARBA:ARBA00040914};
GN ORFNames=D5H75_06355 {ECO:0000313|EMBL:RJL34108.1};
OS Bailinhaonella thermotolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Bailinhaonella.
OX NCBI_TaxID=1070861 {ECO:0000313|EMBL:RJL34108.1, ECO:0000313|Proteomes:UP000265768};
RN [1] {ECO:0000313|EMBL:RJL34108.1, ECO:0000313|Proteomes:UP000265768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 75507 {ECO:0000313|EMBL:RJL34108.1,
RC ECO:0000313|Proteomes:UP000265768};
RA Tang S., Feng Y.;
RT "YIM 75507 draft genome.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Drug:H(+)
CC antiporter-3 (DHA3) (TC 2.A.1.21) family.
CC {ECO:0000256|ARBA:ARBA00038075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJL34108.1}.
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DR EMBL; QZEY01000002; RJL34108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A4B1R2; -.
DR OrthoDB; 4204059at2; -.
DR Proteomes; UP000265768; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265768};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 223..430
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 400..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 42858 MW; D585BC8485959B10 CRC64;
MISGVKAGGA LGLVRSHGAF RLLWTARSVS FLGDSLSLVA LMLHVAETTG QALAVALLLL
VGDFAPALLG PLAGAVGDRF EPRRVMVACE LAQAALVAAM ALWTPALPAL LVLVALRAVA
GQVFQPVSRA IVPALVRDRD LEPANAAIGF GTNAGETLGP LLAALLLPLA GVRGVLLTDA
ATFLLSAVLI ARLPRAPREP APGRGSLLRD TADGLRHIAG APLLRAVGLG YFAIVAFNGI
DDVALVFLAT DTLRGGGSAA GLLLAAVGAG LLAGYALLGR ARRPLPMPPL LVAGFAVSSA
GNLLTGLAWA VAAAFTVQAV RGLGIAAMDV AANTLVQRTV PAAYLSRVFG TLYGAIGVAA
ALAYVGGGLL LDATGPRAAL VVAGAAGLLA TLLTAAALRR VPPPGDPGDP GDPRDPASPG
DLAGPGPPPS
//