ID   A0A3A4F741_9MICC        Unreviewed;       360 AA.
AC   A0A3A4F741;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:RJN32310.1};
GN   ORFNames=D3250_00095 {ECO:0000313|EMBL:RJN32310.1};
OS   Nesterenkonia natronophila.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Nesterenkonia.
OX   NCBI_TaxID=2174932 {ECO:0000313|EMBL:RJN32310.1, ECO:0000313|Proteomes:UP000266615};
RN   [1] {ECO:0000313|EMBL:RJN32310.1, ECO:0000313|Proteomes:UP000266615}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M8 {ECO:0000313|EMBL:RJN32310.1,
RC   ECO:0000313|Proteomes:UP000266615};
RA   Menes R.J., Iriarte A.;
RT   "Nesterenkonia natronophila sp. nov., an alkaliphilic actinobacteriume
RT   isolated from a soda lake, and emended description of the genus
RT   Nesterenkonia.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJN32310.1}.
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DR   EMBL; QYZP01000001; RJN32310.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A4F741; -.
DR   OrthoDB; 9786288at2; -.
DR   Proteomes; UP000266615; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000266615}.
FT   DOMAIN          7..213
FT                   /note="Chalcone/stilbene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          238..357
FT                   /note="Chalcone/stilbene synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   ACT_SITE        152
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   360 AA;  37800 MW;  F5436509BD6CB0EB CRC64;
     MPTRIASIGT SVPPTSLSQV DLRDFFAAQP GRDRLARRYI SAAFDAAGID SRSTAISGLG
     GTPDGVFVAE DGSLLRPTTG VRNALYREAA PRLAAEAARS AVAEAAISAA DITHLISVSC
     TGFFAPGIDY HLIRDLGLRP TVERSHLGFI GCAAALPALR LATQITQAQP DAVVLVVCVE
     LCSLHVRESS DPEQIVASSV FADGAAAAVV TADEQVGRSG GLLLDRFASA LTDEGESDMV
     WTIGDHGFEM RLSAEVPRII GREIRDAVDK FLGTEEPPDT WAVHPGGRSV LDRVENGLNL
     PAEALAASRT VLRDCGNMSS ATILFILRRM MADPTVTGSI AALAFGPGLT VESALLRKAL
//