ID A0A3A4L9G1_9NOCA Unreviewed; 1192 AA.
AC A0A3A4L9G1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=D5S18_01130 {ECO:0000313|EMBL:RJO79902.1};
OS Nocardia panacis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2340916 {ECO:0000313|EMBL:RJO79902.1, ECO:0000313|Proteomes:UP000266677};
RN [1] {ECO:0000313|EMBL:RJO79902.1, ECO:0000313|Proteomes:UP000266677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM PH 21724 {ECO:0000313|EMBL:RJO79902.1,
RC ECO:0000313|Proteomes:UP000266677};
RA Miao C.;
RT "YIM PH21274 draft genome.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJO79902.1}.
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DR EMBL; QZFU01000006; RJO79902.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A4L9G1; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000266677; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000266677}.
FT DOMAIN 16..376
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 377..700
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 851..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1192 AA; 126499 MW; FFBD6B5DCA251BED CRC64;
MAPVTPQRIA DALGLPTPTD EQAAVIAAPP GPTLVVAGAG AGKTETMAAR VVWMVANRLV
LPDEVLGLTF TRKAAQQLTS RIRTRLARLA GSPLLRELDP AGGLRAQLAG AEPEISTYHS
YAGRLLSEHG LLLPVEPAAT LLTQTQLWQL AHQVVRTWDG DLDTERTPVS VTEAVLALSG
QLAEHLVEPE QLAEAHTELD KLVNTLPAGP RQRGGPSQTL RAIVQAQRER VALLPLVLRL
AEALRRRGAL DFGAQMSLAA RLAAEHPEVA TAERRRFRLV LLDEYQDTGH AQRILLAALF
GGGPVESGSP ATHDHDSPSG GEVSRLAVTA VGDPMQSIYG WRGASAANLP RFATDFPSAP
GVPAPTLPLL TSWRNPPEAL ALANLVAEPL RRNAKAAGGV TVDALRAKPA AGPGIVALAL
TETVAEERDW VADRIAAEWA PARLGGDPPP TSAVLVRRNA DAAPLAEALR AKGLPVEIVG
LGGLLATPEV ADILATLRLI AEPGAGSAAM RVLTGARWRI GVTDLAALAR RARDLSIGRP
RSGETTEITD AAALDGALRE VAPEPAEQAG LADAIADPGP QEEYSALGYA RIEELGRELS
LLRERSGQPL TELVADIERT IGVGVETQAR RAMSGTGAGR EHLDAFAEVV AGYAADSGAS
LGGLLAFLAA AESVENGLEP GEVEVARDRV QVLTVHAAKG LEWAVVAVPH VVRGVFPSGA
ASGTWLGAPA ELPTSLRGDR QQEDSADGVP VLDLSDVGDR ADLERAIKAH KEALEVRRID
EERRLFYVAL TRTERTLLVS AHHWSESGSS PKGPSDFLLE LKSANESPDG PATGVLTVDH
WADAPEPDAV NPFTDNPAAA EWPRDPLGSR RDPIEQGAAL VHAALIELRS HKTEPDRQTS
DPTRLDDLSP EFLPEPPDDP DHPPEFEDPD LDFPPEDPDF PFGPAELDDQ PGSNPDDPEG
WAADVDALLS ELASAEATAR EVELPGQLPA TALVELRADP AKLAARLRRP LPYPPNPLAR
RGTAFHAWVQ RWFASSGLLG FDELPGAADG GAPEAADADL TRMQEAFLNS AWSTRTPIEV
EVPFETSLAG TVIRGRIDAV FTEPGGGWLV VDWKTGAEPK PAEESAVAVQ LAVYRLAWAR
LMAARTGSDE RSMLEKIGAA FHYVRTGRTI APRHLAGPRE LAELIRTSAP AE
//
