ID   A0A3A5MAC3_9MICO        Unreviewed;       347 AA.
AC   A0A3A5MAC3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Alpha-ketoacid dehydrogenase subunit beta {ECO:0000313|EMBL:RJT87077.1};
GN   ORFNames=D6T64_16730 {ECO:0000313|EMBL:RJT87077.1};
OS   Cryobacterium melibiosiphilum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Cryobacterium.
OX   NCBI_TaxID=995039 {ECO:0000313|EMBL:RJT87077.1, ECO:0000313|Proteomes:UP000272015};
RN   [1] {ECO:0000313|EMBL:RJT87077.1, ECO:0000313|Proteomes:UP000272015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hh39 {ECO:0000313|EMBL:RJT87077.1,
RC   ECO:0000313|Proteomes:UP000272015};
RA   Liu Q., Xin Y.-H.;
RT   "Novel species of Cryobacterium.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJT87077.1}.
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DR   EMBL; QZVS01000092; RJT87077.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A5MAC3; -.
DR   OrthoDB; 3457658at2; -.
DR   Proteomes; UP000272015; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
FT   DOMAIN          27..202
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   347 AA;  36908 MW;  AC954CEE1626D0F6 CRC64;
     MTPTSTTGTS AAGTSAADTA ASAAANLPMT KALNAGLRQA MLNDPKVILM GEDIGPLGGV
     FRVTEGLIKE FGDKRVLDTP LAESGIIGTA IGLAMRGFRP VCEIQFDGFV FPGFDQITSQ
     LARMRNRHEG GLIMPVVIRI PYGGHIGSIE HHQESPEAYF AHTPGLRVVS PSNPHDAYWM
     MQQAIASNDP VIFFEPKSRY WPKGEVVYAE SGIDLHASRV VRVGSDVTVV GHGAMVSVLL
     QAAEIAATEG ISLEVIDLRS ISPIDFGPIL ASVEKTGRLV VAQEAAGFVS VGSEIAATVA
     ERAYYSLEAP VLRVSGFDTP FPPAAVETHF LPSPDRVLEA VDRVLAY
//