ID A0A3A5MT50_9MICO Unreviewed; 837 AA.
AC A0A3A5MT50;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Polynucleotide kinase-phosphatase {ECO:0000313|EMBL:RJT91019.1};
GN ORFNames=D6T64_02675 {ECO:0000313|EMBL:RJT91019.1};
OS Cryobacterium melibiosiphilum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Cryobacterium.
OX NCBI_TaxID=995039 {ECO:0000313|EMBL:RJT91019.1, ECO:0000313|Proteomes:UP000272015};
RN [1] {ECO:0000313|EMBL:RJT91019.1, ECO:0000313|Proteomes:UP000272015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hh39 {ECO:0000313|EMBL:RJT91019.1,
RC ECO:0000313|Proteomes:UP000272015};
RA Liu Q., Xin Y.-H.;
RT "Novel species of Cryobacterium.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJT91019.1}.
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DR EMBL; QZVS01000053; RJT91019.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A5MT50; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000272015; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07423; MPP_Prp_like; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041780; MPP_PrpE-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024028; PNKP_bac.
DR InterPro; IPR032380; PNKP_ligase_dom.
DR NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR PANTHER; PTHR42850:SF7; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE PRPE [ASYMMETRICAL]; 1.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16542; PNKP_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000313|EMBL:RJT91019.1};
KW Transferase {ECO:0000313|EMBL:RJT91019.1}.
FT DOMAIN 181..374
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 465..832
FT /note="Polynucleotide kinase-phosphatase ligase"
FT /evidence="ECO:0000259|Pfam:PF16542"
SQ SEQUENCE 837 AA; 90749 MW; 2E738C8E2462F69F CRC64;
MILPLPVMSL VVLVGASGSG KSTFAATHFA PFETLSSDFF RGLVSNDEND QAATAAAFEA
LRFVAGKRLD AGLLTVIDAT NVQADARRSL IELARAHDVL PVAVVLDVPE GVCVARNAAR
ADRSFGASVV KRQHDQLRRS LKQLGKEGFR RVHVLNGVEE IAAAQFAREP LLNDRSGEKG
PFDAIGDVHG CRSELETLLG RLGYDVVFDE SGRAVDAVHV EGRRAVFLGD LVDRGPDTPG
VLRLVMGMVA AGHALAVPGN HEAKLVRALE GKKVQPSHGL AETLAQLSSE TEEFRREVLQ
FCRDLVSHLV LDEGRLVVAH AGLIEKYHGR ASGRVRAFAL FGDTTGETDE YGLPVRLPWA
ADYRGTATVL YGHVPTLEAE WVNGTMCLDT GCVFGGTLSA LRYPEKEVVS VAAEQVWYAP
VVPLKPVEVS RDPSLLRIDD VLGKQMVETR VFGKVGIRED NAAGALEVMS RFATDPRRLV
YLPPTMSPPA ESALEGVLEH PAEAFAAYRR EGLERVICEE KHMGSRAVVL LTRDPARFGA
ADGWRGAVHT RTGRPFFGEA ETSEFLARLD RAAEAAGLWD EFGGSWLLFD AELLPWSLKA
GALIREQFAS VAAAATSALP AAVGVLQTAV DRGVDVGELL ARTQRRAGNA FAYRDAYRRY
SQSSAVQLAP FQLLASEGAG HLGREHSWHL GVADRLAVVD GEFIRRTRSI EVDLTSAESE
AAATLWWEEL TAGGGEGMVV KPVAGLVRGS RSLAQPGIKV RGAEYLRIIY GPDYLDPANL
ARLRDRDVGH KRSMALREYA LGVEAVERFV ADEPLWRVHQ AVFGVLAMES EPVDPRL
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