ID   A0A3A5MV09_9MICO        Unreviewed;       830 AA.
AC   A0A3A5MV09;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   ORFNames=D6T64_01515 {ECO:0000313|EMBL:RJT91639.1};
OS   Cryobacterium melibiosiphilum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Cryobacterium.
OX   NCBI_TaxID=995039 {ECO:0000313|EMBL:RJT91639.1, ECO:0000313|Proteomes:UP000272015};
RN   [1] {ECO:0000313|EMBL:RJT91639.1, ECO:0000313|Proteomes:UP000272015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hh39 {ECO:0000313|EMBL:RJT91639.1,
RC   ECO:0000313|Proteomes:UP000272015};
RA   Liu Q., Xin Y.-H.;
RT   "Novel species of Cryobacterium.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJT91639.1}.
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DR   EMBL; QZVS01000043; RJT91639.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A5MV09; -.
DR   OrthoDB; 9810148at2; -.
DR   Proteomes; UP000272015; Unassembled WGS sequence.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.20.272.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR022754; DNA_pol_III_gamma-3.
DR   InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02397; dnaX_nterm; 1.
DR   PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR   PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR   Pfam; PF13177; DNA_pol3_delta2; 1.
DR   Pfam; PF12169; DNA_pol3_gamma3; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE   4: Predicted;
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW   Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT   DOMAIN          36..180
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          536..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          798..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         830
FT                   /evidence="ECO:0000313|EMBL:RJT91639.1"
SQ   SEQUENCE   830 AA;  83900 MW;  29281D24CDC78ADD CRC64;
     MVTALYRRYR PETFADLIGQ SQVTEPLMTA LRTNRVNHAY LFSGPRGCGK TTSARILARC
     LNCAEGPTDT PCGVCPSCIE LARDGGGSLD VVEIDAASHN GVDDARDIRE RAIFAPARDR
     YKIFILDEAH MVTPQGFNAL LKIVEEPPEH VKFIFATTEP EKVIGTIRSR THHYPFRLVP
     PGPMLEYVQQ MCDTEKMQVA PGVLPLVVRA GGGSPRDTLS LLDQLMAGSD GASIEYDRAV
     ALLGYTSAAL LDEAVDAIGA RDAASAFDAV DRVIQTGQDP RRFVEDLLER MRDLIIVAAT
     SAAGAAAVLR GVAPDELDRM ATQAAQFGPA ELSRTADILN AALTEMSGAT SPRLHLELMI
     ARALIPATDD STRGALARVE RLERRVGVAG DVELAAAAPA AAAPAAFVPP AAPIAANPRI
     EPAPAAPAAQ PAASVTAPRV HPVGPVSVQQ LRDAWPEVLE VVRAAKVSAW LVVYNARVLE
     LRGGEVLVLS FPNEADLASF KQRPAPGQGI SDFLRAALLE VLGLSVKFVA RADGGPGGSG
     GSGGPSSPSG SGPSGAGAAA PVAVADTPVT DAAPAPAPGS GPVPWGSPTA AAPGLALAAP
     VAAEPVLAAP VEVDVEVDAG VDAGKGAELG AAPTVAAEPV DVDSTLVADA GSAAPVDTDV
     FADSSVAPNA VVVADSAVDV GVDLDANASH TSVTTPEVIS GPESITAGSE VTATPAVTAA
     PEVTAAPEVT AAPDVTTAPE VTAAPEITAG SEVTTVSEAP AVPGATAAPE VAPAASRAEV
     VPAATSTGWA TVAIPGSAGG AALAPVSDTP APAEPARAAA PAEERAVAAP
//