ID A0A3A6QTA5_9VIBR Unreviewed; 675 AA.
AC A0A3A6QTA5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha {ECO:0000313|EMBL:RJX75603.1};
GN ORFNames=DZ860_02705 {ECO:0000313|EMBL:RJX75603.1};
OS Vibrio sinensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=2302434 {ECO:0000313|EMBL:RJX75603.1, ECO:0000313|Proteomes:UP000273252};
RN [1] {ECO:0000313|EMBL:RJX75603.1, ECO:0000313|Proteomes:UP000273252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BEI233 {ECO:0000313|EMBL:RJX75603.1,
RC ECO:0000313|Proteomes:UP000273252};
RA Li Y.;
RT "Vibrio isolated from the Eastern China Marginal Seas.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJX75603.1}.
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DR EMBL; QVMU01000001; RJX75603.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A6QTA5; -.
DR OrthoDB; 9763189at2; -.
DR Proteomes; UP000273252; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 1..447
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 120..317
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 591..667
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 675 AA; 74595 MW; 159AAA1370056EF5 CRC64;
MIKRVLIANR GEIACRIIKT AKRMAIETVA VYSDADKHSL HVKQADYAEH IGPSPASESY
LNIDAIIVAA KKWQADAIHP GYGFLSENAL LAQACCDNDI VFIGPSSRAI EQMGSKSQAK
TIMANAKVPL VPGYHGADNS VSHLLAEAEK IGYPVMLKAT QGGGGKGMRV VHNASEMPLA
IDGAQRESLS SFGDDQLLIE KCILKPRHVE IQVFADAHGH CLYLSDRDCS IQRRHQKVVE
EAPAPGLSEP LRQKMGQAAV LAAKAINYVG AGTVEFLLDE DEQFYFMEMN TRLQVEHPVT
ELITNIDLVE WQFNIASGNA LPITQHQITH YGHAIELRVY AEDTNNNFMP STGRIDYMMT
PPSNHHIRLD SGIEQGNQIS EFYDPMISKL ITWGETRDIA LTQLKQALKQ YQICGVTTNI
GYLYSIIDQA AFADSKLNTD FLVEHQDSIA QLQNIAPSIW LTFAAVARRL HLVSAKSEAS
PAPSSQGFRL SQNNQFRFNF TRGSENSEVL LTDNNQYSFD SFKVTIDSDI SHAFVVDIDI
NIDQSKQITI ELNGVRYCYS ALIDQHDTTI FFLGQQRTFA HHASYQPIDD TTEDLSPSAP
LNGLISAILV NEGDSVESGQ PLLVLEAMKM EYTIFAPQPA MIESILYQIG DQVQHGAVLV
QLLAESKDSP MNTEG
//
