ID   A0A3A6TPL9_9GAMM        Unreviewed;       337 AA.
AC   A0A3A6TPL9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=aspartate carbamoyltransferase {ECO:0000256|ARBA:ARBA00013008};
DE            EC=2.1.3.2 {ECO:0000256|ARBA:ARBA00013008};
GN   ORFNames=D5R81_19325 {ECO:0000313|EMBL:RJY02332.1};
OS   Parashewanella spongiae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Parashewanella.
OX   NCBI_TaxID=342950 {ECO:0000313|EMBL:RJY02332.1, ECO:0000313|Proteomes:UP000273022};
RN   [1] {ECO:0000313|EMBL:RJY02332.1, ECO:0000313|Proteomes:UP000273022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 22492 {ECO:0000313|EMBL:RJY02332.1,
RC   ECO:0000313|Proteomes:UP000273022};
RA   Wang G.;
RT   "Phylogeny of the Shewanellaceae, and recommendation for two new genera,
RT   Pseudoshewanella and Parashewanella.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001363};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004852}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000256|ARBA:ARBA00008896}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RJY02332.1}.
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DR   EMBL; QYYH01000219; RJY02332.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A6TPL9; -.
DR   OrthoDB; 9774690at2; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000273022; Unassembled WGS sequence.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   NCBIfam; TIGR00670; asp_carb_tr; 1.
DR   PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR   PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000273022};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003634}.
FT   DOMAIN          8..148
FT                   /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02729"
FT   DOMAIN          159..315
FT                   /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF00185"
SQ   SEQUENCE   337 AA;  37373 MW;  A560BE925B598311 CRC64;
     MTQLEGSHIL SVNQLSLDSI NTIFSVAARM QPYALRQKRT NVLDGAILGN LFFEPSTRTR
     VSFGSAFNLL GGSVCETVGM ASSSLTKGES LYDTAKVLST YSDVIAMRHP EPFSVQEFAK
     GSSVPVINGG DGANEHPTQA LLDLFTIEKE LKAKNKAIDG MHIALVGDLK HGRTVHSLSK
     LLCLHKNIHF SLLSPKELQM PSYVVDDIVN AGHKVSIHDA IEGYASGADI LYQTRIQEER
     FPSQDEANKY RGKFKLNQQI YTEHCKDTAV IMHPLPRDSR SAANELDNDL NDNPNLAIFR
     QADNGLLIRM ALFALTLGVD RQLEQHERPV NWFVRQS
//