ID A0A3A9EQ68_9FIRM Unreviewed; 416 AA.
AC A0A3A9EQ68;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein {ECO:0000256|HAMAP-Rule:MF_01074};
DE Short=P2TMN nickel insertion protein {ECO:0000256|HAMAP-Rule:MF_01074};
DE EC=4.99.1.12 {ECO:0000256|HAMAP-Rule:MF_01074};
DE AltName: Full=Nickel-pincer cofactor biosynthesis protein LarC {ECO:0000256|HAMAP-Rule:MF_01074};
GN Name=larC {ECO:0000256|HAMAP-Rule:MF_01074,
GN ECO:0000313|EMBL:RKJ40938.1};
GN ORFNames=D7X94_05925 {ECO:0000313|EMBL:RKJ40938.1};
OS Acutalibacter sp. 1XD8-33.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Acutalibacter.
OX NCBI_TaxID=2320081 {ECO:0000313|EMBL:RKJ40938.1, ECO:0000313|Proteomes:UP000270929};
RN [1] {ECO:0000313|EMBL:RKJ40938.1, ECO:0000313|Proteomes:UP000270929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1XD8-33 {ECO:0000313|EMBL:RKJ40938.1,
RC ECO:0000313|Proteomes:UP000270929};
RA Liu C.;
RT "Murine metabolic-syndrome-specific gut microbial biobank.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the biosynthesis of a nickel-pincer cofactor
CC ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel
CC delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide
CC (P2TMN), to form the mature cofactor. Is thus probably required for the
CC activation of nickel-pincer cofactor-dependent enzymes.
CC {ECO:0000256|HAMAP-Rule:MF_01074}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide =
CC Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide;
CC Xref=Rhea:RHEA:54784, ChEBI:CHEBI:49786, ChEBI:CHEBI:137372,
CC ChEBI:CHEBI:137373; EC=4.99.1.12; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01074};
CC -!- SIMILARITY: Belongs to the LarC family. {ECO:0000256|HAMAP-
CC Rule:MF_01074}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKJ40938.1}.
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DR EMBL; RAZF01000005; RKJ40938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A9EQ68; -.
DR OrthoDB; 9765625at2; -.
DR Proteomes; UP000270929; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051604; P:protein maturation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1380; Transcriptional regulatory protein pf0864 domain like; 1.
DR HAMAP; MF_01074; LarC; 1.
DR InterPro; IPR002822; Ni_insertion.
DR NCBIfam; TIGR00299; nickel pincer cofactor biosynthesis protein LarC; 1.
DR PANTHER; PTHR36566; NICKEL INSERTION PROTEIN-RELATED; 1.
DR PANTHER; PTHR36566:SF1; NICKEL INSERTION PROTEIN-RELATED; 1.
DR Pfam; PF01969; Ni_insertion; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01074};
KW Nickel {ECO:0000256|ARBA:ARBA00022596, ECO:0000256|HAMAP-Rule:MF_01074};
KW Reference proteome {ECO:0000313|Proteomes:UP000270929}.
FT REGION 67..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 45371 MW; 9BC65FEAFFD4A36E CRC64;
MKTLYIECNM GAAGDMLTAA LLELHPDREG FLRRLNGLGL PGVQVSAAPA VKCGVTGTHV
SVAVHGQEEH SHDVSPGHTH EHHHDHNHHE HEHHHDHEHG HDHDHHHSGM HDIQHIVSHL
DLPEKVREDV LAVYGLIAQA ESYAHGAPVS EIHFHEVGTL DAVADVTAVC MLMHELAPER
VVCSPIHVGS GQVRCAHGIL PVPAPATAHI LQGVPTYGGQ VQGELCTPTG AALLRHFAGE
FGPAPMMRVE KTGYGMGTKD FEAMNAVRAM LGEMDEAKTQ AAELRCNLDD MTPEAIAFAA
ERLLEAGAFD VFTTAIGMKK SRPGILLTCL CRLEDRETMT RLMFAHTTTL GIRESLCGRY
TLRRTESAVS TQYGTVRVKE SRGWGVERKK PEYEDLARIA RENGLTLAQA AESLQA
//