ID A0A3A9GAP5_9FIRM Unreviewed; 671 AA.
AC A0A3A9GAP5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=D7Y06_13920 {ECO:0000313|EMBL:RKJ63795.1};
OS Roseburia sp. 1XD42-69.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=2320088 {ECO:0000313|EMBL:RKJ63795.1, ECO:0000313|Proteomes:UP000279120};
RN [1] {ECO:0000313|EMBL:RKJ63795.1, ECO:0000313|Proteomes:UP000279120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1XD42-69 {ECO:0000313|EMBL:RKJ63795.1,
RC ECO:0000313|Proteomes:UP000279120};
RA Liu C.;
RT "Murine metabolic-syndrome-specific gut microbial biobank.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKJ63795.1}.
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DR EMBL; RAZG01000028; RKJ63795.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A9GAP5; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000279120; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013739; Beta_galactosidase_C.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08533; Glyco_hydro_42C; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000279120}.
FT DOMAIN 10..377
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 390..601
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT DOMAIN 616..668
FT /note="Beta-galactosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08533"
SQ SEQUENCE 671 AA; 77113 MW; FD038EE97DD45DF7 CRC64;
MDKLYYGAAY YLEYMPVQRL DKDIAMMKKA GINLARIGES TWSTYEPQEG IFDFSQLEQV
LDAMEEAGIS VIVGTPTYAV PSWMVKSHPD VLALTKEGRG IYGHRQIMDI THPVYLFYSE
RIIREMMKRT AHRKCVIGYQ LDNETKYYGT AGENVQRRFV KYLRVKFKDD LNALNREFGL
DYWSNRLDAW EDFPDVRGTV NGSLGAEFEK FQRALVSEFL SWQAGIVGEY KREEQFITHN
LDFDWRGHSY GVQPNADHYD IAKCLTIAGA DIYHPTQDEL TGKEIAFGGD LIRSLKGDNY
LILETQAQGF PCWTPYKGQL RLQAFSHIAS GANAVEYWHW HSIHNSLETY WKGLLSHDLE
ENETYIEACR VGAEFEKYGK FLVNLKKKND VAILVSNEAL TALEWFGIEA AAASNEGIKY
NDVLRWVYDT LYEHNVECDF VWEESQNLNE YKMIVVPVLY AADERVLKKL NDYINNGGVL
VATFKSGFAN ENVKVYHSVQ PHIIHQALGV TYHQFTFPKN VVLSGDITCG AENFYAEKFM
ELLIPEEDTQ VLASYGHYNW KDYAAVTRHP FGEGFGYYLG CMTDKRVLWK VFDMALKDAG
LDVPKAEFPL ILRKGRNEEG KAFWFYLNYS PEVQRAVHEG ILARDIFTKE QVDGGGTFEV
KGWDLRILAE S
//
