ID A0A3A9GKV4_9FIRM Unreviewed; 950 AA.
AC A0A3A9GKV4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:RKJ65053.1};
GN ORFNames=D7Y06_10805 {ECO:0000313|EMBL:RKJ65053.1};
OS Roseburia sp. 1XD42-69.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=2320088 {ECO:0000313|EMBL:RKJ65053.1, ECO:0000313|Proteomes:UP000279120};
RN [1] {ECO:0000313|EMBL:RKJ65053.1, ECO:0000313|Proteomes:UP000279120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1XD42-69 {ECO:0000313|EMBL:RKJ65053.1,
RC ECO:0000313|Proteomes:UP000279120};
RA Liu C.;
RT "Murine metabolic-syndrome-specific gut microbial biobank.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKJ65053.1}.
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DR EMBL; RAZG01000018; RKJ65053.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A9GKV4; -.
DR OrthoDB; 9757901at2; -.
DR Proteomes; UP000279120; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000279120};
KW Transferase {ECO:0000313|EMBL:RKJ65053.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..324
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 605..921
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 950 AA; 107272 MW; 0422BF6FA03A9BEC CRC64;
MFETVKEYII NFFKSRLFVL SAAMILLSAI LIQQVFVLQI VNGEEYLNNY RLKIEKKREL
KSTRGNIYDR NGNLLAYNEL AYSITIEDNG SYGDTKEKNT SVNQELYQIL LKMDANGDTI
DNDFEIVRKD NGSYEFNVEG KAKQRFLADV YGHPSVDSLK FNNKLGYDEG KATAEQVMEY
LQSSRKFGIA EKYEGDMAYR ITVIRYAMSE NSFQRYISTT IATDVSDETV AYVSENADKL
QGVEVEDDTI RRYVDSKYFA HIIGYTGKIS QEEYEDLSKE NEDYSLTDVI GKSGIERYLD
GELQGTKGSE TVYVDNMGKV VETTERTEPK AGGNAYLSID AELTKAVYDL LEQEIAGIVY
DKMINVKNYD PSSERKESDI KIPIDDVYFA LINNNVIDTK HFSAKDASAA EQGVYSAFQA
KQSAVLSEIR TELTDMPTPF GALLEEEEDY ISYIVNLLKD EKILVSDRID TEDSLYKQWA
EGNVSLMEYL NYAIAQNWID ITRFSVEEKY SDSDEIYRAL LDYLIEELGE DNDFSKYIYK
YMIKQELIAG AQLCVILYDQ GVLEYDESQV FALTSGDISA YNFIREKVQN LEITPAQLAL
DPCSGSCVIT DVKTGEVLAM VSYPGYDNNR LANVVDAEYF AKLNSDLSNP QYNYATQERT
APGSTFKPLV AVAGFSEGVI DTSTIIRDEG RFTRLEEKGP TCWAYPSNHG SINVSQAIEH
SCNYYFYEVG YRLSLNGFTY NEDKGIKTLQ KYAQLFGLND NTGIEIPESE PKVADEYPIT
ASIGQSNNSY TTSQLARYIT AVANKGTVYQ ETLLKELKDS EGNVIKTYEP TVKNTVDILD
FSQWNSIHEG MRMVAEGLSC FKDFRIPVAG KTGTAQQVKN RANHALFVGF APYENPRISI
ATKIAFGYTS HNAADVSRDI LSYYFKVEDR EDLINGRASV IDESANSFAD
//