ID   A0A3A9GX66_9FIRM        Unreviewed;       458 AA.
AC   A0A3A9GX66;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=GHKL domain-containing protein {ECO:0000313|EMBL:RKJ62807.1};
GN   ORFNames=D7Y06_16445 {ECO:0000313|EMBL:RKJ62807.1};
OS   Roseburia sp. 1XD42-69.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=2320088 {ECO:0000313|EMBL:RKJ62807.1, ECO:0000313|Proteomes:UP000279120};
RN   [1] {ECO:0000313|EMBL:RKJ62807.1, ECO:0000313|Proteomes:UP000279120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1XD42-69 {ECO:0000313|EMBL:RKJ62807.1,
RC   ECO:0000313|Proteomes:UP000279120};
RA   Liu C.;
RT   "Murine metabolic-syndrome-specific gut microbial biobank.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKJ62807.1}.
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DR   EMBL; RAZG01000041; RKJ62807.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A9GX66; -.
DR   OrthoDB; 9778566at2; -.
DR   Proteomes; UP000279120; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd16935; HATPase_AgrC-ComD-like; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032834; NatK_C.
DR   PANTHER; PTHR40448; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR   PANTHER; PTHR40448:SF1; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF14501; HATPase_c_5; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000279120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          354..455
FT                   /note="Sensor histidine kinase NatK C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14501"
SQ   SEQUENCE   458 AA;  52783 MW;  B4F0D9F76CC7E3F0 CRC64;
     MEIENMTFYW DMISKVFWFL TNFATAGIYA WFLKPFLPGK RQACAVGFSY FISMFLLKVI
     PLEMWGIVAY SMGCGVIFIS MYLVDKKNMR QKIFLAILSL LFQWIAHGAG QPVYSGLLYA
     LGRNSHIRLE IFTILYSVIE LLYFLLRCAL TFGMVKIVNI VYRDKREELS CYELVLMLLP
     VSLSVAVYYL KAYFCSVYEG DLGISVWHNH EMFTYLDMLF AILSYGVILA VLVFYQKIKK
     TQQEERENAV LAGQMADMRN HICQVEKMYE DIRSIRHDMG NHIMILENLY RKSQWGEAEQ
     YAKRLTDAMG ESFFHVKSKN PVTDVILEEI WKRAFEMGID FRCDFFFGRD IPVDAFDMSV
     ILNNGLGNAL EGTNGEHPFI SVFSSRKNNV FLIEIQNSFH GKLLWDENGE VPLSTKKQGE
     GHGYGLGNIK KIAGKYHGDI AVKSEEGRFI LTVMLLLA
//