ID   A0A3A9H3U1_9FIRM        Unreviewed;       350 AA.
AC   A0A3A9H3U1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:RKJ67796.1};
GN   ORFNames=D7Y06_04585 {ECO:0000313|EMBL:RKJ67796.1};
OS   Roseburia sp. 1XD42-69.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=2320088 {ECO:0000313|EMBL:RKJ67796.1, ECO:0000313|Proteomes:UP000279120};
RN   [1] {ECO:0000313|EMBL:RKJ67796.1, ECO:0000313|Proteomes:UP000279120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1XD42-69 {ECO:0000313|EMBL:RKJ67796.1,
RC   ECO:0000313|Proteomes:UP000279120};
RA   Liu C.;
RT   "Murine metabolic-syndrome-specific gut microbial biobank.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000256|ARBA:ARBA00003283}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000256|ARBA:ARBA00008857}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKJ67796.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RAZG01000006; RKJ67796.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A9H3U1; -.
DR   OrthoDB; 9801717at2; -.
DR   Proteomes; UP000279120; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   PANTHER; PTHR30349:SF41; INTEGRASE_RECOMBINASE HI_1414-RELATED; 1.
DR   PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000279120}.
FT   DOMAIN          6..99
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000259|PROSITE:PS51900"
FT   DOMAIN          123..315
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51898"
SQ   SEQUENCE   350 AA;  40318 MW;  D1729DEA27E2A0AF CRC64;
     MKIKDEFLIR AMRDFFQIYL PKQKCYSKNT VDSYRYAINL FIDYMQEKQS VTLLSMGTDD
     INRDTVSGFL EWLSDSRKNS PGTCNQRLMA LKSFAGYLGL RDFSMTSVYA ETCLVPVRKE
     PAKTVSFLSE SALKEFLKQP DVGKPTGLRN QFLMILMYDT AARCQEVLDI RIGDFCLNVV
     SPYVYLKGKG DKTRAVPLMD VTVRHLRQYL NRFHESEPMH LEDYLFYTVT HNQRHQMSPD
     TIAAFMKKYG ESAKATCPEM PERIHPHLMR HTRAMHLYRN GMPLALLSDF LGHSSLETTR
     VYAYADTEMK RNAIVKSTPK ISDEDEIPAC CCQCRSGIPD GIFLFVCPLF
//