ID   A0A3A9SR50_9FIRM        Unreviewed;      1030 AA.
AC   A0A3A9SR50;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=TIR domain-containing protein {ECO:0000313|EMBL:RKM61089.1};
GN   ORFNames=D6855_04100 {ECO:0000313|EMBL:RKM61089.1};
OS   Butyrivibrio sp. CB08.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=2364879 {ECO:0000313|EMBL:RKM61089.1, ECO:0000313|Proteomes:UP000281491};
RN   [1] {ECO:0000313|Proteomes:UP000281491}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB08 {ECO:0000313|Proteomes:UP000281491};
RA   Hivarkar S., Lanjekar V.B., Dhakephalkar P.K., Dagar S.;
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKM61089.1}.
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DR   EMBL; RAIR01000002; RKM61089.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3A9SR50; -.
DR   OrthoDB; 89550at2; -.
DR   Proteomes; UP000281491; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015032; ThsB__TIR-like_domain.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF08937; ThsB_TIR; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281491};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          3..144
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1030 AA;  116789 MW;  95C95981FA1857B5 CRC64;
     MINHFNAFIS YKHADLDNKI AASIVRDLEH YHIPRKIQKS TGVKKIDRIF RDKDELPITS
     DLNDTISQAL YNADYLIVIC STNTKKSTWV EREIEVFLKN HTMNQILTVL ADGEPYEVIP
     KILLTGKKEV VDEDGVTRTV EMPFEPLSCD YRLPYRRAKA EELPRMAAAL IGCSYDELIN
     RHRQYKMRRM TAIASGVMAL SLGFAGYMFY SNTLIHKNYL ESLKNQSRNL ANQAEKVLED
     ENRLEAMQLS LFALPDGEGD ERPVTPEAIR AVTKSSMAYT SLEGGNIDIV WNYRMPNHVN
     DMKLTSDAKY FGARDTSGVI IVWDAKTHKQ VVYYDDYQQE SEDFTFIGND KLIIRCEKSA
     RAFDLTSGEM LWTLTDKDGE YNFIYASDVF DYGNDSILIA GSQGHIDIVS MKDGSITKSF
     DILTKEETDS YYINHFAMSD DRKKLAFCEA TRYSISDDNY RVGEYDFESG EKTFSDTYEG
     WSRQLLYIGD KILMDIPPFE SGTSSSRLYD YDFVTEGHTL VRCLSSGTLT QDWESELVTY
     DVSIESKFLP LENGNVAYST GDTCKVWNPQ TGEELGNYRL NDSIIDISDL DKDGEPLFIT
     QGGATGSPSM NGDTPGVSLI SRFADNLSGA VVGNGVYAQK YLSRDIVYYA SGVYDEDWTQ
     IEGIPEYNIS GIEHFLSGNT LCVLTEVDEG CRVFFVDTKE KSYLGDVIIK DGIKPSRYKI
     LGVYAGTLYL ASCQDNRFEI TEVEIESKKI DKLLINDDTW DYDPKCAMAD GKLVYIDTQH
     GKENKAEEID LATGEKKTVV IPDWGRDLFF VPESNDVYVL AETDYLVHMD NETYSEVKLP
     EEWEKTKYVA GDGQALAISN AEVIKLFDAD QNLISEISCG NVEPLGMVIT KIGGQRLLLV
     AYQDGTLFRY NAENGEFVGK ADLSVSYMAY LFDSSIEADD ENGFLYVQVG DLIDIIETDT
     WIETTRVMNC FGHDKETDTF LTYSYENNKK EGRIGYFEHY SVERLIQKTK DYLQGEEMSE
     DQKSMYGITD
//