ID A0A3A9YUV0_9ACTN Unreviewed; 701 AA.
AC A0A3A9YUV0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=D7294_20235 {ECO:0000313|EMBL:RKN39765.1};
OS Streptomyces hoynatensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1141874 {ECO:0000313|EMBL:RKN39765.1, ECO:0000313|Proteomes:UP000272474};
RN [1] {ECO:0000313|EMBL:RKN39765.1, ECO:0000313|Proteomes:UP000272474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 29097 {ECO:0000313|EMBL:RKN39765.1,
RC ECO:0000313|Proteomes:UP000272474};
RX PubMed=24243968; DOI=10.1099/ijs.0.055640-0;
RA Veyisoglu A., Sahin N.;
RT "Streptomyces hoynatensis sp. nov., isolated from deep marine sediment.";
RL Int. J. Syst. Evol. Microbiol. 64:819-826(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKN39765.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RBAL01000012; RKN39765.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A9YUV0; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000272474; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013739; Beta_galactosidase_C.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08533; Glyco_hydro_42C; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000272474}.
FT DOMAIN 14..392
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 404..622
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT DOMAIN 649..698
FT /note="Beta-galactosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08533"
SQ SEQUENCE 701 AA; 78246 MW; F749546A42891FF6 CRC64;
MSQLPARVLF GAAYYHEYQP TPRLEADLDL MRRAHFSVIR VGESVWSTWE PENGVFDLDW
LQPVLDGAHT RGIGVILGTP TYAIPPWLQR TYPELNAERR TGQPAGWGAR QEIDYSHPAF
LFHAERLIRR IVARYAGHPA VIGYQVDNEP GNEIFHNRGV FQRFVDHLRH TYGSVAEINE
QWGLTYWSHR LSTWADLWTP DANAQPQYAL AWRRFQGTLT SDFIGWQAEI VREYAREDQF
VTTCISYPRR TVRDDELAAR LDVTAGNPYY RMQDALALPD ARSAGQDWST DGTWALYRSA
DRMYSSRQEP FLVTETNAQA ISHPWVNEPA YDGQWRQAAW ALVSRGARMI EYWHWHTLHF
GTETYWGGIL PHSAEPGRVY RELAGLGGEF EKAGALVAGL VPDADVALVY STDTKWSLEG
HPALPLPGGV EPDRASYQTL FDAFYRGAFD AGLQSRILHP GQLFAQDPAD FAARQPLLVA
AGLLIADDAQ LRWLERYAAA GGHLLLGIRT GYEDEEARAR QERKPAFLTE AAGVWYDEFS
TLRSPLPVEA AEGSPLTLPE EAAATRWADG LCLPEEGAAE VLARYVHPHF GRWPAVTTRA
HHAGRVTYLG TVPDPALAAA VLGWCAAGSA PRTWRPGSPS QTVTGATAAD GTRLRFVHNW
SWEPGTCPLP GAVRDVLSGE ELPAGAELRL GPWDVRVLAE R
//
