ID A0A3A9ZJD2_9ACTN Unreviewed; 559 AA.
AC A0A3A9ZJD2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=D7223_10845 {ECO:0000313|EMBL:RKN48482.1};
OS Micromonospora endolithica.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=230091 {ECO:0000313|EMBL:RKN48482.1, ECO:0000313|Proteomes:UP000281726};
RN [1] {ECO:0000313|EMBL:RKN48482.1, ECO:0000313|Proteomes:UP000281726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12677 {ECO:0000313|EMBL:RKN48482.1,
RC ECO:0000313|Proteomes:UP000281726};
RX PubMed=15046305; DOI=10.1078/072320204322881781;
RA Hirsch P., Mevs U., Kroppenstedt R.M., Schumann P., Stackebrandt E.;
RT "Cryptoendolithic actinomycetes from antarctic sandstone rock samples:
RT Micromonospora endolithica sp. nov. and two isolates related to
RT Micromonospora coerulea Jensen 1932.";
RL Syst. Appl. Microbiol. 27:166-174(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKN48482.1}.
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DR EMBL; RBAK01000003; RKN48482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3A9ZJD2; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000281726; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:RKN48482.1};
KW Helicase {ECO:0000313|EMBL:RKN48482.1};
KW Hydrolase {ECO:0000313|EMBL:RKN48482.1};
KW Nucleotide-binding {ECO:0000313|EMBL:RKN48482.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000281726}.
FT DOMAIN 196..350
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 404..552
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 559 AA; 61603 MW; EF59E82440B40CD4 CRC64;
MSGGPLIVQS DKTLLLEIDH PDAQACRMAI APFAELERSP EHVHTYRLTP LGLWNARAAG
HDAEGVVDAL LKYSRYPVPH ALLVDVAETM DRYGRLQLAN DPAHGLVLRA LDRVVLIEVA
KSKKLAGMLG TKLDDDTIQV HPSERGRLKQ ALLKLGWPAE DLAGYVDGEA HPIDLATDGK
DGSKPWTLRS YQREAVEAFW AGGSGVVVLP CGAGKTLVGA AAMAEAKATT LILVTNTVAG
RQWKRELIAR TSLTEEEIGE YSGERKEIRP VTIATYQVLT SRRGGAFTHL DLFGARDWGL
VVYDEVHLLP APIFRFTADL QARRRLGLTA TLVREDGREG DVFSLIGPKR YDAPWKDIES
QGWIAPAQCT EVRVTLTDAE RMSYATAEAE ERYRMAATAR TKMPVVRALV ERHPQEQVLV
IGGFLDQLHQ LGEYLDAPII QGSTTNKERE RLFDAFRSGA IRTLVISKVG NFSIDLPEAA
VAIQVSGTFG SRQEEAQRLG RVLRPKADGR QAHFYTVVSR DTIDTEYAAH RQRFLAEQGY
AYTIVDADDV LGPSLPSLD
//
