ID   A0A3B0J1F3_DROGU        Unreviewed;       639 AA.
AC   A0A3B0J1F3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE            EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
GN   ORFNames=DGUA_6G002749 {ECO:0000313|EMBL:SPP75024.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP75024.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC       family. {ECO:0000256|ARBA:ARBA00005796}.
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DR   EMBL; OUUW01000001; SPP75024.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0J1F3; -.
DR   STRING; 7266.A0A3B0J1F3; -.
DR   OMA; SEHMFIT; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043648; P:dicarboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00819; PEPCK_GTP; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR   Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR   HAMAP; MF_00452; PEPCK_GTP; 1.
DR   InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008209; PEP_carboxykinase_GTP.
DR   InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR   InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR   PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)-RELATED; 1.
DR   Pfam; PF00821; PEPCK_GTP; 1.
DR   Pfam; PF17297; PEPCK_N; 1.
DR   PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1.
DR   SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR   SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR   PROSITE; PS00505; PEPCK_GTP; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Kinase {ECO:0000313|EMBL:SPP75024.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Pyruvate {ECO:0000313|EMBL:SPP75024.1};
KW   Transferase {ECO:0000313|EMBL:SPP75024.1}.
FT   DOMAIN          45..274
FT                   /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17297"
FT   DOMAIN          278..635
FT                   /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF00821"
SQ   SEQUENCE   639 AA;  70162 MW;  260F011AD8485F2D CRC64;
     MLLKGVQLLR GGLVGPPKSY NFRLVCRSLS VQYGDAKVLT PAVKQYVEKC VQLCTPERVH
     ICDGSAGESK LLQGLMLKQG TILPLPKYDN CWLARTNPAD VARVESKTFI CTEHREQTVP
     VTPKATPGTL GNWISEADLQ AAIGERFPGC MKGRTMYVIP FSMGPVGSPL SKIGIEITDS
     PYVVESMKIM TRAGNPVLDV LRTGDGQFVK CLHSVGTPKS GIQVQSSWPC DPERTIILHK
     PADNEIVSYG SGYGGNSLLG KKCFALRIGS TIAKREGWLA EHMLILGITN PAGKKIYVAA
     AFPSACGKTN LAMMTPTLPG YKVECVGDDI AWMKFDSQGV LRAINPENGF FGVAPGTSRA
     TNPIAMDTIF RNTVFTNVAS TSDGGVYWEG MESAQLKDLT VTDWLGKLWS KESGKPAAHP
     NSRFCTPATQ CPIIDPAWED SAGVPISAIL FGGRRPAGVP LVYEARDWTH GVFMGAAMRS
     ESTAAAEHKG KAIMHDPFAM RPFFGYNFGD YLSHWLSMEK RGKVPKIFHV NWFRKSSEGK
     FLWPGFGDNS RVLDWIFRRV QGEKCFEDSP IGRLPSKDAL NVSGMKGNID LAQLFDLPKD
     FWQQEALEIE RYFEEQVGGH LPRPVAEQLA ELKARVSNM
//