ID   A0A3B0J1X1_DROGU        Unreviewed;       734 AA.
AC   A0A3B0J1X1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Blast:Mitotic spindle assembly checkpoint protein MAD1 {ECO:0000313|EMBL:SPP72952.1};
GN   ORFNames=DGUA_6G000351 {ECO:0000313|EMBL:SPP72952.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP72952.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MAD1 family.
CC       {ECO:0000256|ARBA:ARBA00008029}.
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DR   EMBL; OUUW01000001; SPP72952.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0J1X1; -.
DR   STRING; 7266.A0A3B0J1X1; -.
DR   OMA; RDFYKQM; -.
DR   OrthoDB; 8224at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 3.30.457.60; -; 1.
DR   Gene3D; 6.10.250.90; -; 1.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR   PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR   Pfam; PF05557; MAD; 1.
DR   SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   REGION          40..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          138..260
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          390..445
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          511..538
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          567..636
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        53..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  85429 MW;  FFF3E24292ED4CA2 CRC64;
     MDDIRSSLDN MVDQFNDSIT HSAPKKLLFN RVSISLSDDS ATLPKKRRME QESPNCSLNT
     SNGSLNSSTT DPNGILQTNK LRAELIGTKA RLNQMQEKLK QNDKKRRMEL SLAESKVSSL
     QAQSDYTSNK LVRLLEEMEK MRGVESSYKE ELRRAKAELA ALKLKYDDTV SKLKNEKAQQ
     EHDARDVQLC INNELAEYRR HAQRSDLELQ STLNELESIR QRHDEYKVRV SGFEELRANF
     EKQQQSLKVA EERIKDLEFE IQSYTDWKQV TKVSQERLAS IPEMDAELQR LRIHNRQLNK
     IIGDKLLLEE QVHEYKTRLD KEEGARAEAA SLQVKLTHTE QELKEWVKVA QDHCLANTLV
     SPAALRSRIE QLLQGDIVHV SEKYASESES KQMRNAVRDL EQKVRVYLKN IEDLNMNLKR
     HKNFKDRLQR KLRTVSRERD FYKQMVDNFD KDLTMSNASV AEMTQDMQVR YRVDVLERTV
     TGYKDLCATL DREIQAMRDQ EQLSDPSSED YENVKKELDT LRIENDRLRR RKEEQELEMM
     QRCLRQDISS PVSKVVHFAD NPAAEAYESS KNMFEKLQAE IERLRRHNKK LEDANEQHLN
     ETTTSTGGMT MNFKELNKLR AELESANAKL GKTKEHFMAA RKEFRDVVYM LLGYRIDRVG
     YKSNYRVTSM YAESPDDYFS IALSESNDLA LLETPYSETL QPALDQQLAA NNSFPPFFSS
     LTLDLFQRAT VTIN
//