ID   A0A3B0J2I8_DROGU        Unreviewed;      1084 AA.
AC   A0A3B0J2I8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Blast:Patched domain-containing protein 3 {ECO:0000313|EMBL:SPP73322.1};
GN   ORFNames=DGUA_6G000778 {ECO:0000313|EMBL:SPP73322.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP73322.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; OUUW01000001; SPP73322.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0J2I8; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF92; PATCHED-RELATED, ISOFORM A; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        162..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..617
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        624..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        650..672
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        693..719
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        725..749
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          162..319
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          814..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        822..841
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        905..940
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        944..958
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1007..1036
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1084 AA;  123267 MW;  8FFFC9DE13B8679E CRC64;
     MIRREVFQEL RTLDNIIQNA SSTYDGDTYT YKDNCARWEN ECFENDILNL DALMDDLEAG
     QLNLTFPFMF NPVTWDAHLF PVFFGGTKLT EDNYVISVPA IQLVYFVTAD NKRQDAKGAE
     WEETFLRVVG QAEESGLFKH ISVSYFASRT LDHELEKNTK TVVPYFSSTF LLMGLFSIIT
     CMMGDAVRSK PFLGLMGNVS AIMATLAAFG LAMYCGIEFI GINLAAPFLM IGIGIDDTFV
     MLAAWRRTKA KMPVAERMGH MMSEAAVSIT ITSVTDFISF LIGIISPFRS VRIFCTYSGF
     AVCFTFLWHI TFFAACMAIS GYRERKNLHS IFGCRVQPMS VAIKEKRNFL YKALMAGGID
     GADPDNPIDN KDHMLMAFFK DKMSTVINNK WCKIIIILAF ATYLAGACYG ITQIKEGLER
     RKLSREDSYS VEFFDREDDY YREFPYRMQV IIAGPLNYSD PLVQQQVENL TSTLEHTSYV
     TSKRYTESWL RSFLSFLERN NELLNATIDD EQSFIDAVKE HWLFPGNPFS LDVRFNDDET
     QIIASRFLIQ AVNITDTNHE KEMVRDLRKI CRDSPLNASI FHPYFVFFDQ FELVRPVSLQ
     AMIIGAIIMM IISFIFIPNI LCSLWVAFSV ISIELGVAGY MALWDVNLDS ISMINLIMCI
     GFSVDFTAHI CYTYMSSKKR SPKARVREAL HSLGLPIIQG SSSTILGIVA LLLAQSYIFL
     VFFKMVFLVV FFGAMHGLFL LPVLLSLFGP GSCLTWTGRD DGSEDEIDDS LDERKQEKPF
     SQSYYMQYPT MGINGPYGSK GFLGAPYKAY GVDEKDQGLG TSGEDSSESS SSRSQRRQQL
     ANAAAEEEAA TQDPRRRYEE GWRRSSYQNI YGPNASIIAG HVQAQFQAQP DLYGQQVSAA
     EWRQRLDAHE QQQQQRSRQR RSPYENYDMD MQRARRNSHG DVIDIMQGTP NSSVDERLRR
     PYTSQDRAML SGGSGDEGSY RQQPGRDSPP TAALPPLGHA SSAKRYHRRR SSEDSTRHHQ
     RWPANIEERR ARRTQSPALR QPETAPPPSF AYRSSSHHNL YQPHKSGHKA TKQPPTYQYG
     DYYH
//