ID   A0A3B0J5W3_DROGU        Unreviewed;       630 AA.
AC   A0A3B0J5W3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Blast:Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 {ECO:0000313|EMBL:SPP77257.1};
GN   ORFNames=DGUA_6G007921 {ECO:0000313|EMBL:SPP77257.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP77257.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Sulfur metabolism; sulfate assimilation.
CC       {ECO:0000256|ARBA:ARBA00005050}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the sulfate
CC       adenylyltransferase family. {ECO:0000256|ARBA:ARBA00009290}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the APS kinase
CC       family. {ECO:0000256|ARBA:ARBA00007268}.
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DR   EMBL; OUUW01000002; SPP77257.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0J5W3; -.
DR   UniPathway; UPA00097; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000103; P:sulfate assimilation; IEA:UniProtKB-UniPathway.
DR   CDD; cd02027; APSK; 1.
DR   CDD; cd00517; ATPS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR   HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR   InterPro; IPR002891; APS_kinase.
DR   InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR024951; Sulfurylase_cat_dom.
DR   InterPro; IPR002650; Sulphate_adenylyltransferase.
DR   NCBIfam; TIGR00455; apsK; 1.
DR   NCBIfam; TIGR00339; sopT; 1.
DR   PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR   PANTHER; PTHR11055:SF1; PAPS SYNTHETASE, ISOFORM D; 1.
DR   Pfam; PF01583; APS_kinase; 1.
DR   Pfam; PF01747; ATP-sulfurylase; 1.
DR   Pfam; PF14306; PUA_2; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          233..388
FT                   /note="ATP-sulfurylase PUA-like"
FT                   /evidence="ECO:0000259|Pfam:PF14306"
FT   DOMAIN          396..622
FT                   /note="Sulphate adenylyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01747"
SQ   SEQUENCE   630 AA;  71089 MW;  F0B3169A9BE623B7 CRC64;
     MPNPPIGFYP HIKRRCLQVA TNVTEQKHHV TRETRGKNLG LCRGFRGCTV WLTGLSGAGK
     TSIAFELEAY LVSRGIPAYG LDGDNIRTGL NKNLGFTPAE REENIRRVGE VAKLFADSGV
     VSICSFVSPF ADDREMARKI HKDAGLKFYE IFVDTPLDVC ETRDVKGLYK KAREGVIKGF
     TGITQEYERP HKPELVVSTH ECTVQESTQK LVTLLEQEGI IPRSLRDVDL LPELYPSESI
     ASDALRHEAE SLKALPISTV ELQWVQVLSE GWAYPLRGFM REDEYLQTLH FNTLQSGMDG
     SYRENHSVPI VLSATAEDKE RLDGVSALTL THEGKPVAIL RRPEFYYQRK EERLARQFGT
     SNPNHPYSKQ VLESGEYLVG GDLAVIERIR WDDGLDQYRL TPNELRRKFK ELNADAIFAF
     QLRNPIHNGH ALLMQDTKRQ LLERGFKQPV LLLHPLGGWT KDDDVPLDVR MRQHQAVLDA
     GVLRREDTVL AIFPSPMMYA GPTEVQWHAK ARMNAGANFY IVGRDPAGMP HPDKGAYPDG
     NLYDATHGAR VLKMAQGLDS MEILPFRVAA YDNSASRMAF FEPQRKDEFE FISGTKMRTL
     AKTGASPPVG FMEPEAWKIL ATYYQNLQQA
//