ID A0A3B0JAR9_DROGU Unreviewed; 2129 AA.
AC A0A3B0JAR9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Blast:Myosin-M heavy chain {ECO:0000313|EMBL:SPP77563.1};
GN ORFNames=DGUA_6G008260 {ECO:0000313|EMBL:SPP77563.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP77563.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; OUUW01000002; SPP77563.1; -; Genomic_DNA.
DR STRING; 7266.A0A3B0JAR9; -.
DR OMA; LMEFDAT; -.
DR OrthoDB; 9305at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 1734..1925
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1973..2105
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..519
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2129 AA; 230447 MW; 64FA41840F4DF5E3 CRC64;
MYDKSKKSWS QRLKTLGSSP HSGGDASLGT VSGMQAMQQL QLHLQHQHQQ QQQQQQLQQQ
QLAQHLPQHH GHHGHHLAAY QLPPPVAAEF LPSALSRSMK YAEPWIYGTV RGIPARPSYG
YHHQHQHQHH HHAHAAAIFA TDGGGGDSPL RGALAVVICS CAEYLNGTKR DVKKASVCKK
CKGSRLPLAT IGGSTGGGTV RLPAVSSSSS GGRSSRPMAA TMRVVSATKK SRPSILDPQK
DPYDLMRRTR LLSPEPTSAS SSKDSPSKEG KSRSREAATI STTRGRTRTR APLPPSKGTS
TAAPPAAAAV TSAAPEPADC WLMEDNDALL RGSGLTARAS STGSSRRSIL RCNVNPYDLI
SIENGKQKQQ SSGKSSVYAD DFDVADAQLH DDELERQREK QGKRKKFYGS NVTAIAGQRI
SLGKEKPIDP SDSSDSYERI IIASSGSSVE PLASAPPVVG PRRPPRNKKA DESTGNHHQE
VPATATMPVV TPSKAPPTDA ENDAEDDDEN DDDDDDDGHD GSSPFTLLTV TPTMPAIKSI
LKRRPSTLEV PPAGVILLPE GGLSTAPLLT PSGKSQFYIP TPTKATAATP TNTAAAAAAA
ATATSTPTST IPGANGVTMT PTSTSTSTTS SRKKVQFMVE DKIIATTTDT PPTTDDSSDA
SHAFVATVTA GSGSGSAADE ATTTTTTRTT TRTNYEYYNR KRNAAAAATA AVGRAAAVAA
SAAAQQETFA ADVDDEHNFT TSAEPTATAT ATATALHIKP DSLHYEDVLL LPQLSGHQIF
DKSDSNSNSS RSSEPATEMQ PKLLLPAQED EEDPAPAAAC HLGSRFPHVT ANVVSVLPDG
TATTAATAMA TQKTTAANRD YDDDDEHNDK DESNDKSHSS SSSSSIHTNN DNDNDINGHG
LEEDKNEGEK KVARQKDTAR PAASQKRAAQ TTQSRNPIRR AHSERHLSAA PITAATVAPP
AAVRNSSSSF SSISKTTPPL PRCSVSSVSG PQNVILNFKD TMALRTKSNR SDSRDLFQRR
PTEPPPPPPP KGPLAETAKG LELPPQGINK SAATPSDSQA KAKAETLTLT LTPIPTSTPA
QPRQQQQQRT VVRVAPYQQS GEGAHEVHRL KISHSEDDDT DLGVQLRRRP STRLQLSAEE
EATPKKTSIL ISGDDCYSTM NLSADAAQPL YQSSVVVNSN SNSQAVSTGG VCINVSSAEE
EEQQLNHLNT LRTQQMLGGT GTGLGIAIIP IRSSEINLQR SVSCISSTSS SSTSSSGSSS
GRGRTLIRLD YDRERGTGAG TSTTPINTPP AISSTPATPP PLASASDSSS PTASPLVQHE
TELLKILRNP VEAVKRNLVP HVCGLRSGSA SDTAGRTKKM QDAVTTIVPR SSPKEGSFIA
KLLQDPMLGQ VAEGLETETV AELIENSLQR LQQARQAIDM SGTKDHDDMS RLISASLQRI
RVERTTKEED RLSNRGSIGS ANSFASAHNY ELFDFAGGND SDCYQSCSSV LTASGIIEEE
PQPPEVEAEP ELDAATRAKF YQLLVDATLA EIEHSTHTET EVEESEHHYE SIRLNGDPIY
EEINEKPPPL PLSAPPLNDA ELEKKAARSI FEGASKYDIL SYLVDAKERG LAREESFDYS
NNPKIIEEEA TDTLGELEKR VEDRDSGQSN MNSLSPPPQS FICGGGGKCG SDVERQDSGV
GSETSKSSRS KYQATPTVLH LCEDCDGAVE MQVGESGVLY APLVCRKCGK KRVERKEIIT
EIVETEEKYG RDLQIILEEF CHPMLVAGLL TQEQLSAIFL NTEDLLENNQ TLAERMRDAL
DMSLEQGDDD LLTVNIGRIF LDFTQMLHAF ESYCVRQAGA SLLLANLEKE KELLRIFLKV
SQMENAVLRR MNLNSFLMVP VQRVTKYPLL LARLYKVTPS QIDGRELLKQ AQEKIELHLN
HINQEAKDVP TKLWRRISSS SPNRRASCEI DMINIKLRKM AIDVLEWNHD EVRFAMEGKL
LYTQPTDSNW KKARTIKLTP VNALLVTNGK PSANYRAEKA MSDKLNFPKH TGIREASLLL
VKEKCGRYTL IREPLYLDRC VVCSEADWDD YFEVQEISSK DTFIFKAEDG VRTKQWYTQL
QYHAQGMGAW RKRRNALANI MINGMLARS
//
