ID A0A3B0JC49_DROGU Unreviewed; 1417 AA.
AC A0A3B0JC49;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Blast:Roundabout homolog 2 {ECO:0000313|EMBL:SPP79957.1};
GN ORFNames=DGUA_6G012882 {ECO:0000313|EMBL:SPP79957.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP79957.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; OUUW01000004; SPP79957.1; -; Genomic_DNA.
DR OMA; IDDIHGH; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF108; ROUNDABOUT HOMOLOG 3; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017185793"
FT TRANSMEM 932..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 127..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 222..308
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 313..408
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 417..506
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 529..626
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 697..801
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 806..905
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 723..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1417 AA; 154238 MW; 10BA9AD65A0ADFE2 CRC64;
MSDVVLPMLL MLSGLNGLTQ VAALKGENPR IIEHPMDTTV PKNDPFTFNC KAEGNPTPTI
QWYKDGRELK TDAGSHRMML PAGGLFFLKV IHSRRESDAG TYWCQAKNEF GVARSRNATL
QVAFLRDEFR LEPQNTRVAQ GEVALMECGA PRGSPEPQIS WRKNGQTLNL SAGNKRIRIV
DGGNLAIQDS RQSDDGRYQC VVKNVVGTRE SATAFLKVHV RPFLIRGPQN QTAVVGSSVV
FQCRIGGDPL PDVLWRRTAS GGNMPLRRVH VLEDRSLKLD DVTLEDMGEY SCEADNAVGS
ITATGILTVH APPKFVIRPK NQLVEIGDEV LFECQATGHP RPTLYWSVEG NSSLLLPGYK
DGRLEVTLTP EGRSVLAITR FAREDSGKVV VCNALNAVGS VSSRTVVSVD TQFELPPPII
EQGPVNQTLP VKSIVVLPCR TLGTPVPQIS WYLDGIPIDV QEHERRNLTE AGALTISDLQ
RHEDEGLYTC VASNRNGKSS WSGYLRLDTP TNPNIKFYRA PELSTYPGPP GKPQLVEKGE
DSVTLSWTRS NKVGGSSLVG YVIEMFGKNE TDGWVAVATR VQNTTYTQSG LVPGVNYFFL
IRAENSHGLS LPSPMSEPIA VGTRYFNSGL DLSEARASLL SGDVVELSNA SVVDSTSMKL
TWHIINGKYV EGFYVYARQL PNPIVNNPAP VSSHTNPLLG PTSATASASA SALISTKPNI
AAAGKRDGET PQQQQQQQQQ QQPSTSSTKY RMLTILNGGG ASSCTLTGLV QYTLYEFFIV
PFYKSVEGKP SNSRVARTLE DVPNEAPFGM EALLLNASAV FLKWKAPELK AQHGILLNYH
VVVRGIDTAH NFSRILTNVT IDAASPTLVL ANLTEGVMYT VGVAAGNNAG VGPYCAPATL
RLDPITKRLD PFINQRYPIN QDHVNDVLTQ PWFIILLGAI LAILMLSFGA MVFVKRKHMM
MKQSALNTMR GNHTNDVLKM PSLSTRTGNG YWLDASTGGM VWRPSPSGDS LEMQKDHIAD
YAPVCGAVSP GTVGVAGAGG PGGVGAASGI SGVDDIHGGH GSERNQQRYV GEYSNIPTDY
AEVSSFGKAP SEYGRHGNAS PAPYATSSIL SPQQQQQQQR YQQRTVGAGP GTGYGLQRPM
HPHYQQQQQQ PQQIPPGNIY QQMSTTSEIY PSQTGPARSV YSEQFYYPKD KHMHMHITEN
KLSNCHTYEA APGPKQSSPN STQFASVRRQ QLPPGCSIAR DSARFKVINA NAGQLMDQSK
SQTQTQTQSQ TQQNLLDLDG SSFCYNGLAD SGCGGSPSPM AMLMSHEDEQ ALYHTADGDL
DDMERLYVKV DEQQPPLQQQ QLLPLVPQHP SELLQPSPHH QSWRGQSTRG SRKMPQESIN
VKEANELIYA PGSVASERSL LSNTGSGSSG QPPCHNV
//
