ID A0A3B0JFX4_DROGU Unreviewed; 1163 AA.
AC A0A3B0JFX4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
GN ORFNames=DGUA_6G006303 {ECO:0000313|EMBL:SPP81294.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP81294.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; OUUW01000005; SPP81294.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JFX4; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF33; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:SPP81294.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 32..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..324
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 478..566
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 1004..1123
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 709..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 129275 MW; D9D413D5E184E1AB CRC64;
MSGCDQSTVE SLADDPTDSP FDADDCLKVR KYWCFLLSSI FTFLAGLLIV LLWRAFAFIC
CRKEPDLGPN DPKQKEQKAS RNKQEFEGTF MTEAKDWAGE LISGQTTTGR ILVVLVFILS
IASLIIYFVD ASSEEVERCQ KWSNNITQQI DLAFNIFFMV YFFIRFIAAS DKLWFMLEMY
SFVDYFTIPP SFVSIYLDRT WIGLRFLRAL RLMTVPDILQ YLNVLKTSSS IRLAQLVSIF
ISVWLTAAGI IHLLENSGDP LDFNNAHRLS YWTCVYFLIV TMSTVGYGDV YCETVLGRTF
LVFFLLVGLA VFASWIPEIT ELAAQRSKYG GTYSKDPRKR HIVVCGHITY ESVSHFLKDF
LHEDREDVDV EVVFLHRKPP DLELEGLFKR HFTTVEFFQG TIMNPIDLQR VKVHEADACL
VLANKYCQDP DAEDAANIMR VISIKNYSDD IRVIIQLMQY HNKAYLLNIP SWDWKQGDDV
ICLAELKLGF IAQSCLAPGF STMMANLFAM RSFKTSPDTQ AWQNDYLQGT GCEMYTETLS
PSFTGMTFPQ ASELCFSKLK LLLLAIEIKG AEEGVDSKIS INPRGAKIQA NTQGFFIAQS
ADEVKRAWFY CKACHEDIKD ETLIKKCKCK NLATFRKGVR AVQMVGRASD ITRDREDTNL
LNRNVRRPNG TGNGTGAMHH MNNTAAAAAA AAAAGKQVNK VKPTVNVSRQ VEGQVISPSQ
YNRPTSRSSG TGTQNQNGGV SLPAGIADDQ SKDFDFEKTE MKYDSTGMFH WSPAKSLEDC
ILDRNQAAMT VLNGHVVVCL FADPDSPLIG LRNLVMPLRA SNFHYHELKH VVIVGSVDYI
RREWKMLQNL PKISVLNGSP LSRADLRAVN VNLCDMCCIL SAKVPSNDDP TLADKEAILA
SLNIKAMTFD DTIGVLSQRG PEFDNLSATA GSPIVLQRRG SVYGANVPMI TELVNDSNVQ
FLDQDDDDDP DTELYLTQPF ACGTAFAVSV LDSLMSTTYF NQNALTLIRS LITGGATPEL
ELILAEGAGL RGGYSTVESL SNRDRCRVGQ ISLYDGPLAQ FGECGKYGDL FVAALKSYGM
LCIGLYRFRD TSSSCDASSK RYVITNPPDD FSLLPTDQVF VLMQFDPGLE YKPPAVRAPA
GGRGTNTQGS GVGGGGSNKD DNS
//
