ID A0A3B0JGC0_DROGU Unreviewed; 629 AA.
AC A0A3B0JGC0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Blast:Testican-1 {ECO:0000313|EMBL:SPP81195.1};
GN ORFNames=DGUA_6G006192 {ECO:0000313|EMBL:SPP81195.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP81195.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; OUUW01000005; SPP81195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JGC0; -.
DR STRING; 7266.A0A3B0JGC0; -.
DR OrthoDB; 4174283at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16232; EFh_SPARC_TICN; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR13866:SF27; KAZAL-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..629
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017277497"
FT DOMAIN 228..279
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 530..594
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 115..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 566..573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 629 AA; 71747 MW; CFB2BE8336D679F5 CRC64;
MKHSPLIASA CLALVLMSSS LIGSSEAKKK KYVGETGGDF EFIDEINKNT QNKNLGEHKR
WIHDPSSDLC RPLNCKKREI CLLEDEYSAV CVSKKELHKN RDEIITKAKY MEEEAKRRVN
QQDNQDSQDA EDLTNDDEDN SSDSSASNNA PTNVQVNEES DDEDKSLSLG DDDESKEDDV
FYENNIAGGD KQQSQQQQQQ QQQQQQQQQQ QQQIPPAGPP SAIQQDDDEE LDNCKPCPVA
KPTFLCGADN RTYSSLCRLD YHNCIHSTTI RIACKGFCPC KENVDGKRLQ RIAGYNKYNK
KISLEQQQQQ QQQQAYKDSS NNNIMMNSGN IMGGNTNDFN TIMNDKEDNN RHYNHINAQY
TFTPEEIKYD NKHYKYLKYT AYKKDAKYQE DKHKMRSYNE VVEKQQQKFN KNSNLNAYPS
KSAECKPQQL TAIGNRLLDW FSVIMADSKK RRQHSQKSKA HFPPACKTEA KWMFGHLDLN
NDGQLSLQEM YDLEHDQNER CIKPFIDTCD LDTDSSINTR EWCRCFEKTD RPCAAVRRRI
AGDFAGEIGA YAPDCDIQGF YKPTQCHNSV GVCWCVDKHG VEFANTRTRG KPNCESVVNN
AASLTSDDED EGADDEDSAE GSADQMLVF
//
