ID A0A3B0JGJ2_DROGU Unreviewed; 5388 AA.
AC A0A3B0JGJ2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Blast:Protein purity of essence {ECO:0000313|EMBL:SPP79823.1};
GN ORFNames=DGUA_6G012733 {ECO:0000313|EMBL:SPP79823.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP79823.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR EMBL; OUUW01000004; SPP79823.1; -; Genomic_DNA.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 2.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1819..1888
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1819..1888
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 333..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2452..2481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3046..3147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4250..4276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3046..3120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4250..4274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5388 AA; 597269 MW; 009B4A6C3FAED32F CRC64;
MSSHSGGTDW NSVLKALLLS RTGALNKNEV VNLLKAITRC EHEFFDDESS FVQFYTAFAA
LAADKLMQIK SICQTQICQL HDATAVLIRF ILFRLPKVTV YESKWLLAAL KMLCEGRENA
STAVSQFDYS AVAGVVKSSK HPESSNKSIM SIGGSTTGGA AAGGSNDKDS PKLEIKRSRS
DLSSVILQQL LAPLEPGKMT WVPLSEEITD CTEQLLAANV EVFQEANGVD TLLDICVGLP
ILSRYRMKYM ETINAGKPLY LPLTQAEATT VKSSMNHMLT DLSIVGQAYA LIVMQPLTPS
RIEKLSMCGI SALYNAVLTS IATSVLSMGQ ASSSQKQQQQ QQTAAASTSQ GSGGGLSSVQ
TSKDHDEFEE QASGIVNKAL EIYSCIGEMF KSSARMYIYQ NHLCYGSWLL ISGIQGAMGA
SGSASAETAA KAAAAAAAAT KVAAKTETAT APSTPIARVN LFKVQQGFGE LNAAIANHSI
KLLSELIEDL KIESACGQSS LTDPETLPEP AQFDILQNYT SLERIVRVLN TATLHQLFTF
LATVAYRKAC TLKRASTKDR TECDPISYSD STTCLNESMS YSDNSEEDDS ESYLGHWFKE
TLSPETHDDN ANTSSQERSG EQKSALVPKL DEPHEYLELS ADIFCFLDQF LANRHAYMQR
YVKAGVSDQQ MLLMANIIKD FDRDVMRNDS EQQSPPSTAV AVVAGGAGAS GCSAKWQASM
IRFSGAAGRY IHNLISTGLL SEQLQSNLLQ HLAISPWSTD TNTWPLQVYP STLSVLVQIL
LLKPIQEKEA ACLSVWHRLI NTLVEGVCSS TSAADSDYED INIEHAQLLL FLFHSLNLMQ
KKSILLLTAG GVIRCAEVCR GISAERIVRN SQMMLLSRLL VFLEYLMKHL YQAPPELLDQ
VRWILFSVSS MPETQKVSDL INNRAKLNSY CRQDIEEKFR KSAGEYGSNI RPTFYSLVLK
EPEKAYWVSE FKLDGLAWNF ILCTPDKLKY PLLVDALVDI LNIADMSSFA KKDSNDSSSM
HSLCAMQYCF TNTWKLLLGL PPSTSHVEAL RIERAPNLHS LVWSTRMPLS KSHYLIVSSL
IKQGMYTQYA ESLFTQVGDT TADIRYNLKQ TILGVEAFNQ QMSNKGIPRL SELILFDALV
AHMQAVAWAV KEGSKLLRKD CEDSGASERL SSNSAASSGN VGNAADHDHP EVYSSNESID
EEQSKQEDEP GLSTETLERN QMINELLIKL MDSYRYLSDI VREQMLKQLS STTPEHVLNL
IVPIVSDKPA IMLELHAAFL KLLPNEDKQL IANEWPKCLM VNDAAFDGKQ HPVEPYTLNV
IDAHITELTR GSGGVAYSTL HTLKHCLKTI LHLMEYLLPY ASNCCEMDAQ LKPLLIASML
DMRTDYLQGQ SEQCLREILS GLTLEAQKLL LYEHMIGYCY RMLIEFAAEL RQPAAGGTPL
DQERALFNES MLFAVLKTFI KMLEKPTSVQ AMRQFFHDQR TGSLTTLLLS FTGTTLPLSY
ARKMLQFVER LFEQSTQADS QFQHEDLVDC FGDLSSVDVA RLKLWLAHII YGPNVTGGDV
SSSETMDPTC RLLTSIMQPS SSSSSNAQTP TNMATVSAMP SISDQLDAMD IDYDCGAAAT
AAGAAPNTSQ ILSLWQAAQP NPSEESSQAC DHSEGGEQRQ NERNGGLLLS IIKYLVRDQN
KAGPIAAPLF QALLQLGQTL ISPPHDGCDF ADVLQIMITL ADASPARGHV ALFNTTLLWL
ELAKLQLPDK HLRHAENVSA LLRYLSELLQ SIGYRGSRQH MPPWDDELQT DIDDLYDELA
EEEQDSLLDD SDEDTLNNKL CTFSQTQKEF MNQHWYHCHT CNMINTVGVC SVCARVCHKG
HDVSYAKYGN FFCDCGAKED GSCQALSRRL GSGEARDTVG AGGGSSCSYL PSHMSLLAGK
KRSNAGAATG QLQQQGPSTR KDSISSERIQ LLGKLLEPYR ETLQHQEQWM LVVRCILEYF
DVLMPSIREN CTLYSIVGCH RRATAALERL HQLEQSFQIT DQLMFATLGS QEGAFENVRM
NYSGDQGQTI KHLLTSGTIR RVAFCCLSSP HGRRQQLAVS HEKGKVTILQ LSALLKQADA
SKRKLTLTQL SSAPIACTVL SLAANPCNED CLAVCGLKEC HVLTFSSSGS TNEHIVITPQ
LENGNFLKKA MWLPGSQTLL AIVTTDYVKI YDLAVDTISP KYYYLVAVGK IKDCTFMYHQ
QDGSGSYFML SFTSSGYIYT QQLDQQSLAV HGDFYVTNTL ELSHQHIKDI NGQVCGGGVS
IYYSHTLQLL FYSYTSGRSF CSPLTNVNEG VKGIYHLDIN NTAATVTSKS SSTSKVPLQS
LVGWTEVAGH PGLIYASMNT SNNPVILMIT PERIYMQEIK AQSAKARIMD VVGIRHSVAG
TEKTTLLLLC EDGSLRIFSA QPEHTSFWLS PQVQPFGNQL YSSTLLAKNG NSQQAKSKAG
GSSGKLHHRK SNGSHQQQKQ LTAGGQPLFP IDFFEHCNML ADVEFGGNDL LQIYSKQKLK
TRLFSTGMFV ASTKSTGFTL EVINNDPNVV MVGFRVMLGT QDIQRAPVSV TILGRTIPTT
MRKARWFDIP LTREEMFQSD KMLKVMFAKS QDPEHVTLLD SIEVYGKSKE LVGWPDDSEE
IQAPSSGPTP VTATQQSAAA NFGEGFNCIT QLDRMVNHLL EVLDCALHLL GGSAVAAPLR
SKVVKTASGL LLLPTPNPVQ TQARYVLATL YGSRATYHSF KDGVILHFVH GELQAMQPKL
QQLESLQEID PEAFYRLILL VRGVANSRPQ SLTKICQENS YDLVPALMGI VLELHKITPD
LDEPANIVRR GLCQPETIVH CLVEIMYGFA LADPGQVGRM TQYFIDLLKH DATVISHSAK
EALILLLSPR LKRRKAAAMA AVITPPACST PTPQMQALQA VAVSAANDII EEAAAGAAAA
AAAQDQDNAA AVLLEAVEGG VPGQGQPNQQ LLNLEAFMGG GFPRLLGLPE DADDEAIMDI
AIALSLQQHG GADANALQSL QQGLANIQGI RQAAANAAAA SASVSVSAGG SDDEGSNVAT
DGSTLRTSPA EPAGSGGSES GGSGVESIGG TSARSSNFGD HPNTTPPRQS CSSVKDDEQP
GPSGSASGAP AGGSGLSAMS STEDNEINED EKLQKLHDLR IAVLESIIQH LNTFDLCNGL
QAIPLIQVIH MLTTDLNGNN ERDQQVLQEL LQALVEYVEI GKRGAASRME TKCPLNEVRL
ALLALFGVMM GKTKSKQTGT TSPPHQFKDN SSFVASTTAN VLSKSGAFIY ALEALNTLLV
HWKNVLGDPY AAGQAAAPTA SSGGATSGPG VQLLKPIKHG PKPDISILIP QNYLKNYPDI
FESYDGLLTE IIVRLPYQIL RLSSAHPDNY DSSFCEAMTF TLCEYMMLNL NTLLRRQVRK
LLMYICGSKE KFRMYRDGHS LDAHFRVVKR VCNIVSSKTG APYNANPPLL SYDSLVDLTE
HLRTCQEISQ MRTGNWQKFC VVHEDALAML MEIACYQLDD GVSPIIIQLL QAAVCNMPAN
KQQQAPPAVV SASAKLRSER EKSEDTDAYY SKFDPAQCGT FVHQIFRYAC DALIIRFVRI
FLLENNISQL RWQAHSFMTG LFEHANERQR EKLLTIFWNL WPLVPTYGRR TAQFVDLLGY
LTLTTRSITE RLPEFVSRAV EVLRSQNELL CKHPNAPIYT TLESILQMNG YYLESEPCLV
CNNPEVPMAN IKLPSVKSDS KYTTTTMIYK LVQCHTISKL IVRIADLKRT KMVRTINVYY
NNRSVQAVVE LKNRPALWHK ARSVSLQSGQ TELKIDFPLP ITACNLMIEF ADFFETVSGS
SENLQCPRCS AAVPAYPGVC GNCGENVFQC HKCRAINYDE KDPFLCHSCG FCKYAKFDFS
MYARVCCAVD PIESAEDRAK TVSMIHSSLE RADRIYHQLL ANKQLLELLI QKVAEHRIND
RLVEDNMASV HSTSQVNKII QLLAQKYCVE SRASFEELSK IVQKVKACRS ELVAYDRQQQ
DLPPSNLSLS LGAENPTTNR CYGCALASTE QCLTLLRAMA YNYDCRMGLY SQGLVSELAE
HNLRRGTPQI QNEVRNLLVV LTKDNPDACM HLLQLVTSRV KSALMGAIPL ISLEAAVHQE
MTLLEVLLGQ DDFCWEYKLK VIFELFISNC KLPRGPVASV LHPCLRILQS LINPTISSGS
GNGKTVSAID LCSIKLPDGN TIDYRAWLNS DRNHEYLAWS SRMPISQHQQ EAAATAVKPK
SSSSSKTTAD TPPKTKEATR AAYLCEKYGK RWRTNVLDKQ RVTKPLVFNA EWIQPLLFNE
NSRFGRQLAC TLLGALARTH ERKQQALNLL TSFLGHVGEA GEASTEYLAL YRSIATESPW
LQYLVLNGVL GKISALLATE ISKIHCMEEH SLSSDLTLGY ALRRYVELLW LFLECPNIRR
TYKTRLLGPV LESYLALRSL VVQRTRHIDE AQEKMLEMLE EMTSGTEEET RAFMEILIDT
VDKTRMNDIK TPVFIFERLY SIIHPEEHDE SEFYMTLEKD PQQEDFLQGR MLGNPYPSGE
MGLGPLMRDV KNKICTDCEL IALLEDDNGM ELLVNNKIIS LDLPVKDVYK KVWLAEGGDR
DAMRIVYRMR GLLGDATEEF VETLNNKSQE AVDTEQLYRM ANVLADCNGL RVMLDRIGSL
QRISRQRELI QVLLKLFLIC VKVRRCQEVL CQPEIGAINT LLKVLQMCLQ SENDSIQSAV
TEQLLEIMET LLSKAASDTL DSFLQFSLTF GGPEYVSALI SCTDCPNVRN NPSVLRHLIR
VLAALVYGNE VKMALLCEHF KDTLNFKRFD NERTPEEEFK LELFCVLTNQ IEHNCIGGTL
KDYIVSLGIV ERSLAYITEH APCVKPTLLR TDSDELKEFI SRPSLKYILR FLTGLSNHHE
ATQVAISKDI IPIIHRLEQV SSDEHVGSLA ENLLEALSTD AATAARVQQV RDFTRAEKKR
LAMATREKQL DALGMRTNEK GQVTAKGSIL QKIEKLRDET GLTCFICREG YACQPEKVLG
IYTFTKRCNV EEFELKSRKT IGYTTVTHFN VVHVDCHTSA IRLTRGRDEW ERASLQNANT
RCNGLLPLWG PSVLETAFSA SMTRHSSYMQ ESTQRCDISY TSSIHDLKLL LVRFAWERSF
HDDAGGGGPQ SNMHFVPYLL FYSIYMLLSS RSAARDSKTL LTYLTAPPSE KWLECGFEVD
GPLYMSTIAL TLHSRELWNK HKLAHLKRML AVAQARHISP SVLCKALLAP ADRQVKDYSV
YKPYLMMWAL IDMIYNMLFK SVTMPKEEAW PVSLFDYIRK NDEGMLNSTD SILHILTEEL
LPCTSFGEFC DVAGKSIESC LTACCLLLIF YLSFRRTSHT YRTAGQLH
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